Abdelwahed SH - Search Results

1

Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions.

Mehta AP, Abdelwahed SH, Mahanta N, Fedoseyenko D, Philmus B, Cooper LE, Liu Y, Jhulki I, Ealick SE, Begley TP. Mehta AP, et al. Among authors: abdelwahed sh. J Biol Chem. 2015 Feb 13;290(7):3980-6. doi: 10.1074/jbc.R114.623793. Epub 2014 Dec 4. J Biol Chem. 2015. PMID: 25477515 Free PMC article. Review.

2

Catalysis of a flavoenzyme-mediated amide hydrolysis.

Mukherjee T, Zhang Y, Abdelwahed S, Ealick SE, Begley TP. Mukherjee T, et al. J Am Chem Soc. 2010 Apr 28;132(16):5550-1. doi: 10.1021/ja9107676. J Am Chem Soc. 2010. PMID: 20369853 Free PMC article.

3

A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase.

Chatterjee A, Hazra AB, Abdelwahed S, Hilmey DG, Begley TP. Chatterjee A, et al. Angew Chem Int Ed Engl. 2010 Nov 8;49(46):8653-6. doi: 10.1002/anie.201003419. Angew Chem Int Ed Engl. 2010. PMID: 20886485 Free PMC article. No abstract available.

4

Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation.

Philmus B, Abdelwahed S, Williams HJ, Fenwick MK, Ealick SE, Begley TP. Philmus B, et al. J Am Chem Soc. 2012 Mar 21;134(11):5326-30. doi: 10.1021/ja211759n. Epub 2012 Mar 9. J Am Chem Soc. 2012. PMID: 22304755 Free PMC article.

5

Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA.

Mehta AP, Hanes JW, Abdelwahed SH, Hilmey DG, Hänzelmann P, Begley TP. Mehta AP, et al. Among authors: abdelwahed sh. Biochemistry. 2013 Feb 19;52(7):1134-6. doi: 10.1021/bi3016026. Epub 2013 Feb 4. Biochemistry. 2013. PMID: 23286307 Free PMC article.

6

In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone.

Cooper LE, Fedoseyenko D, Abdelwahed SH, Kim SH, Dairi T, Begley TP. Cooper LE, et al. Among authors: abdelwahed sh. Biochemistry. 2013 Jul 9;52(27):4592-4. doi: 10.1021/bi400498d. Epub 2013 Jun 27. Biochemistry. 2013. PMID: 23763543 Free PMC article.

7

Molybdopterin biosynthesis: trapping an unusual purine ribose adduct in the MoaA-catalyzed reaction.

Mehta AP, Abdelwahed SH, Begley TP. Mehta AP, et al. Among authors: abdelwahed sh. J Am Chem Soc. 2013 Jul 31;135(30):10883-5. doi: 10.1021/ja4041048. Epub 2013 Jul 22. J Am Chem Soc. 2013. PMID: 23848839 Free PMC article.

8

Molybdopterin biosynthesis: trapping of intermediates for the MoaA-catalyzed reaction using 2'-deoxyGTP and 2'-chloroGTP as substrate analogues.

Mehta AP, Abdelwahed SH, Xu H, Begley TP. Mehta AP, et al. Among authors: abdelwahed sh. J Am Chem Soc. 2014 Jul 30;136(30):10609-14. doi: 10.1021/ja502663k. Epub 2014 Jul 18. J Am Chem Soc. 2014. PMID: 24955657 Free PMC article.

9

Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase.

Fenwick MK, Mehta AP, Zhang Y, Abdelwahed SH, Begley TP, Ealick SE. Fenwick MK, et al. Among authors: abdelwahed sh. Nat Commun. 2015 Mar 27;6:6480. doi: 10.1038/ncomms7480. Nat Commun. 2015. PMID: 25813242 Free PMC article.

10

Molybdopterin biosynthesis-Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP.

Mehta AP, Abdelwahed SH, Begley TP. Mehta AP, et al. Among authors: abdelwahed sh. Biochim Biophys Acta. 2015 Sep;1854(9):1073-7. doi: 10.1016/j.bbapap.2015.04.008. Epub 2015 Apr 17. Biochim Biophys Acta. 2015. PMID: 25896388 Free PMC article. Review.

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