Begley TP - Search Results

1

Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions.

Mehta AP, Abdelwahed SH, Mahanta N, Fedoseyenko D, Philmus B, Cooper LE, Liu Y, Jhulki I, Ealick SE, Begley TP. Mehta AP, et al. Among authors: begley tp. J Biol Chem. 2015 Feb 13;290(7):3980-6. doi: 10.1074/jbc.R114.623793. Epub 2014 Dec 4. J Biol Chem. 2015. PMID: 25477515 Free PMC article. Review.

2

Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile.

Costello CA, Kelleher NL, Abe M, McLafferty FW, Begley TP. Costello CA, et al. Among authors: begley tp. J Biol Chem. 1996 Feb 16;271(7):3445-52. doi: 10.1074/jbc.271.7.3445. J Biol Chem. 1996. PMID: 8631946 Free article.

3

Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation.

Taylor SV, Kelleher NL, Kinsland C, Chiu HJ, Costello CA, Backstrom AD, McLafferty FW, Begley TP. Taylor SV, et al. Among authors: begley tp. J Biol Chem. 1998 Jun 26;273(26):16555-60. doi: 10.1074/jbc.273.26.16555. J Biol Chem. 1998. PMID: 9632726 Free article.

4

Crystallization and preliminary X-ray analysis of thiaminase I from Bacillus thiaminolyticus: space group change upon freezing of crystals.

Campobasso N, Begun J, Costello CA, Begley TP, Ealick SE. Campobasso N, et al. Among authors: begley tp. Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):448-50. doi: 10.1107/s0907444997014157. Acta Crystallogr D Biol Crystallogr. 1998. PMID: 9761925

5

Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution.

Campobasso N, Costello CA, Kinsland C, Begley TP, Ealick SE. Campobasso N, et al. Among authors: begley tp. Biochemistry. 1998 Nov 10;37(45):15981-9. doi: 10.1021/bi981673l. Biochemistry. 1998. PMID: 9843405

6

Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution.

Chiu HJ, Reddick JJ, Begley TP, Ealick SE. Chiu HJ, et al. Among authors: begley tp. Biochemistry. 1999 May 18;38(20):6460-70. doi: 10.1021/bi982903z. Biochemistry. 1999. PMID: 10350464

7

Thiamin biosynthesis in prokaryotes.

Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J. Begley TP, et al. Arch Microbiol. 1999 Apr;171(5):293-300. doi: 10.1007/s002030050713. Arch Microbiol. 1999. PMID: 10382260 Review.

8

The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase.

Appleby TC, Kinsland C, Begley TP, Ealick SE. Appleby TC, et al. Among authors: begley tp. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2005-10. doi: 10.1073/pnas.259441296. Proc Natl Acad Sci U S A. 2000. PMID: 10681442 Free PMC article.

9

Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.

Campobasso N, Mathews II, Begley TP, Ealick SE. Campobasso N, et al. Among authors: begley tp. Biochemistry. 2000 Jul 11;39(27):7868-77. doi: 10.1021/bi0000061. Biochemistry. 2000. PMID: 10891066

10

The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase.

Begley TP, Appleby TC, Ealick SE. Begley TP, et al. Curr Opin Struct Biol. 2000 Dec;10(6):711-8. doi: 10.1016/s0959-440x(00)00148-2. Curr Opin Struct Biol. 2000. PMID: 11114509 Free article. Review.

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