Deng L - Search Results

1

Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease.

Hanson JE, Pare JF, Deng L, Smith Y, Zhou Q. Hanson JE, et al. Among authors: deng l. Neurobiol Dis. 2015 Feb;74:254-62. doi: 10.1016/j.nbd.2014.11.017. Epub 2014 Dec 4. Neurobiol Dis. 2015. PMID: 25484285 Free PMC article.

2

GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior.

Hanson JE, Weber M, Meilandt WJ, Wu T, Luu T, Deng L, Shamloo M, Sheng M, Scearce-Levie K, Zhou Q. Hanson JE, et al. Among authors: deng l. Neuropsychopharmacology. 2013 Jun;38(7):1221-33. doi: 10.1038/npp.2013.19. Epub 2013 Jan 22. Neuropsychopharmacology. 2013. PMID: 23340518 Free PMC article.

3

Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons.

Hanson JE, Deng L, Hackos DH, Lo SC, Lauffer BE, Steiner P, Zhou Q. Hanson JE, et al. Among authors: deng l. J Neurosci. 2013 Apr 3;33(14):5924-9. doi: 10.1523/JNEUROSCI.3162-12.2013. J Neurosci. 2013. PMID: 23554474 Free PMC article.

4

A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain.

Wang TM, Brown BM, Deng L, Sellers BD, Lupardus PJ, Wallweber HJA, Gustafson A, Wong E, Volgraf M, Schwarz JB, Hackos DH, Hanson JE. Wang TM, et al. Among authors: deng l. Neuropharmacology. 2017 Jul 15;121:204-218. doi: 10.1016/j.neuropharm.2017.04.041. Epub 2017 Apr 27. Neuropharmacology. 2017. PMID: 28457974 Free article.

5

Insensitivity to Pain upon Adult-Onset Deletion of Nav1.7 or Its Blockade with Selective Inhibitors.

Shields SD, Deng L, Reese RM, Dourado M, Tao J, Foreman O, Chang JH, Hackos DH. Shields SD, et al. Among authors: deng l. J Neurosci. 2018 Nov 21;38(47):10180-10201. doi: 10.1523/JNEUROSCI.1049-18.2018. Epub 2018 Oct 9. J Neurosci. 2018. PMID: 30301756 Free PMC article.

6

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist.

Ahuja S, Mukund S, Deng L, Khakh K, Chang E, Ho H, Shriver S, Young C, Lin S, Johnson JP Jr, Wu P, Li J, Coons M, Tam C, Brillantes B, Sampang H, Mortara K, Bowman KK, Clark KR, Estevez A, Xie Z, Verschoof H, Grimwood M, Dehnhardt C, Andrez JC, Focken T, Sutherlin DP, Safina BS, Starovasnik MA, Ortwine DF, Franke Y, Cohen CJ, Hackos DH, Koth CM, Payandeh J. Ahuja S, et al. Among authors: deng l. Science. 2015 Dec 18;350(6267):aac5464. doi: 10.1126/science.aac5464. Science. 2015. PMID: 26680203

7

Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids.

Deng L, Dourado M, Reese RM, Huang K, Shields SD, Stark KL, Maksymetz J, Lin H, Kaminker JS, Jung M, Foreman O, Tao J, Ngu H, Joseph V, Roose-Girma M, Tam L, Lardell S, Orrhult LS, Karila P, Allard J, Hackos DH. Deng L, et al. Neuron. 2023 Sep 6;111(17):2642-2659.e13. doi: 10.1016/j.neuron.2023.05.024. Epub 2023 Jun 22. Neuron. 2023. PMID: 37352856 Free article.

8

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Na_v1.7 Inhibitors for the Treatment of Chronic Pain.

McKerrall SJ, Nguyen T, Lai KW, Bergeron P, Deng L, DiPasquale A, Chang JH, Chen J, Chernov-Rogan T, Hackos DH, Maher J, Ortwine DF, Pang J, Payandeh J, Proctor WR, Shields SD, Vogt J, Ji P, Liu W, Ballini E, Schumann L, Tarozzo G, Bankar G, Chowdhury S, Hasan A, Johnson JP Jr, Khakh K, Lin S, Cohen CJ, Dehnhardt CM, Safina BS, Sutherlin DP. McKerrall SJ, et al. Among authors: deng l. J Med Chem. 2019 Apr 25;62(8):4091-4109. doi: 10.1021/acs.jmedchem.9b00141. Epub 2019 Apr 16. J Med Chem. 2019. PMID: 30943032

9

Cryo-EM reveals an unprecedented binding site for Na_V1.7 inhibitors enabling rational design of potent hybrid inhibitors.

Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC. Kschonsak M, et al. Among authors: deng l. Elife. 2023 Mar 28;12:e84151. doi: 10.7554/eLife.84151. Elife. 2023. PMID: 36975198 Free PMC article.

10

The role and clinical applications of exosomes in cancer drug resistance.

Pan W, Miao Q, Yin W, Li X, Ye W, Zhang D, Deng L, Zhang J, Chen M. Pan W, et al. Among authors: deng l. Cancer Drug Resist. 2024 Nov 4;7:43. doi: 10.20517/cdr.2024.97. eCollection 2024. Cancer Drug Resist. 2024. PMID: 39624083 Free PMC article. Review.

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