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The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein.
Leonard PG, Parkinson GN, Gor J, Perkins SJ, Ladbury JE. Leonard PG, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):421-5. doi: 10.1107/S1744309110004574. Epub 2010 Mar 31. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 20383013 Free PMC article.
H-NS forms a superhelical protein scaffold for DNA condensation.
Arold ST, Leonard PG, Parkinson GN, Ladbury JE. Arold ST, et al. Among authors: leonard pg. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15728-32. doi: 10.1073/pnas.1006966107. Epub 2010 Aug 23. Proc Natl Acad Sci U S A. 2010. PMID: 20798056 Free PMC article.
The human orphan nuclear receptor tailless (TLX, NR2E1) is druggable.
Benod C, Villagomez R, Filgueira CS, Hwang PK, Leonard PG, Poncet-Montange G, Rajagopalan S, Fletterick RJ, Gustafsson JÅ, Webb P. Benod C, et al. Among authors: leonard pg. PLoS One. 2014 Jun 17;9(6):e99440. doi: 10.1371/journal.pone.0099440. eCollection 2014. PLoS One. 2014. PMID: 24936658 Free PMC article.
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors.
Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR 4th, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Du Y, et al. Among authors: leonard pg. Nat Med. 2016 Feb;22(2):194-201. doi: 10.1038/nm.4032. Epub 2016 Jan 18. Nat Med. 2016. PMID: 26779812 Free PMC article.
Identification of potent and selective MTH1 inhibitors.
Petrocchi A, Leo E, Reyna NJ, Hamilton MM, Shi X, Parker CA, Mseeh F, Bardenhagen JP, Leonard P, Cross JB, Huang S, Jiang Y, Cardozo M, Draetta G, Marszalek JR, Toniatti C, Jones P, Lewis RT. Petrocchi A, et al. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1503-1507. doi: 10.1016/j.bmcl.2016.02.026. Epub 2016 Feb 11. Bioorg Med Chem Lett. 2016. PMID: 26898335
69 results