Kelley RF - Search Results

1

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Li B, et al. Among authors: kelley rf. MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517310 Free PMC article.

2

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments.

Kelley RF, O'Connell MP, Carter P, Presta L, Eigenbrot C, Covarrubias M, Snedecor B, Bourell JH, Vetterlein D. Kelley RF, et al. Biochemistry. 1992 Jun 23;31(24):5434-41. doi: 10.1021/bi00139a003. Biochemistry. 1992. PMID: 1351741

3

The tissue factor region that interacts with substrates factor IX and Factor X.

Kirchhofer D, Lipari MT, Moran P, Eigenbrot C, Kelley RF. Kirchhofer D, et al. Among authors: kelley rf. Biochemistry. 2000 Jun 27;39(25):7380-7. doi: 10.1021/bi000182+. Biochemistry. 2000. PMID: 10858285

4

Epitope location on tissue factor determines the anticoagulant potency of monoclonal anti-tissue factor antibodies.

Kirchhofer D, Moran P, Chiang N, Kim J, Riederer MA, Eigenbrot C, Kelley RF. Kirchhofer D, et al. Among authors: kelley rf. Thromb Haemost. 2000 Dec;84(6):1072-81. Thromb Haemost. 2000. PMID: 11154116

5

The tissue factor region that interacts with factor Xa in the activation of factor VII.

Kirchhofer D, Eigenbrot C, Lipari MT, Moran P, Peek M, Kelley RF. Kirchhofer D, et al. Among authors: kelley rf. Biochemistry. 2001 Jan 23;40(3):675-82. doi: 10.1021/bi002013v. Biochemistry. 2001. PMID: 11170384

6

Generation of a humanized, high affinity anti-tissue factor antibody for use as a novel antithrombotic therapeutic.

Presta L, Sims P, Meng YG, Moran P, Bullens S, Bunting S, Schoenfeld J, Lowe D, Lai J, Rancatore P, Iverson M, Lim A, Chisholm V, Kelley RF, Riederer M, Kirchhofer D. Presta L, et al. Among authors: kelley rf. Thromb Haemost. 2001 Mar;85(3):379-89. Thromb Haemost. 2001. PMID: 11307801

7

Kelley RF, Yang J, Eigenbrot C, Moran P, Peek M, Lipari MT, Kirchhofer D. Kelley RF, et al. Biochemistry. 2004 Feb 10;43(5):1223-9. doi: 10.1021/bi035738i. Biochemistry. 2004. PMID: 14756558

8

Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.

Lee CV, Hymowitz SG, Wallweber HJ, Gordon NC, Billeci KL, Tsai SP, Compaan DM, Yin J, Gong Q, Kelley RF, DeForge LE, Martin F, Starovasnik MA, Fuh G. Lee CV, et al. Among authors: kelley rf. Blood. 2006 Nov 1;108(9):3103-11. doi: 10.1182/blood-2006-03-011031. Epub 2006 Jul 13. Blood. 2006. PMID: 16840730 Free article.

9

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation.

Li B, Xi H, Diehl L, Lee WP, Sturgeon L, Chinn J, Deforge L, Kelley RF, Wiesmann C, van Lookeren Campagne M, Sidhu SS. Li B, et al. Among authors: kelley rf. J Biol Chem. 2009 Dec 18;284(51):35605-11. doi: 10.1074/jbc.M109.035170. J Biol Chem. 2009. PMID: 19833734 Free PMC article.

10

Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function.

Kelley RF, Meng YG. Kelley RF, et al. Methods Mol Biol. 2012;901:277-93. doi: 10.1007/978-1-61779-931-0_18. Methods Mol Biol. 2012. PMID: 22723108

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