Chen SC - Search Results

1

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1.

Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. Rettenmaier TJ, et al. Among authors: chen sc. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18590-5. doi: 10.1073/pnas.1415365112. Epub 2014 Dec 17. Proc Natl Acad Sci U S A. 2014. PMID: 25518860 Free PMC article.

2

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis.

Wu VM, Chen SC, Arkin MR, Reiter JF. Wu VM, et al. Among authors: chen sc. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13644-9. doi: 10.1073/pnas.1207170109. Epub 2012 Aug 3. Proc Natl Acad Sci U S A. 2012. PMID: 22864913 Free PMC article.

3

UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area.

Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. Arkin MR, et al. Comb Chem High Throughput Screen. 2014 May;17(4):333-42. doi: 10.2174/1386207317666140323133841. Comb Chem High Throughput Screen. 2014. PMID: 24661212

4

Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.

El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. El-Sakkary N, et al. Dis Model Mech. 2018 Jul 30;11(7):dmm033563. doi: 10.1242/dmm.033563. Dis Model Mech. 2018. PMID: 29925529 Free PMC article.

5

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening.

Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. Sanchez MI, et al. PLoS One. 2019 Dec 18;14(12):e0226270. doi: 10.1371/journal.pone.0226270. eCollection 2019. PLoS One. 2019. PMID: 31851699 Free PMC article.

6

Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.

Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Neitz RJ, et al. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4834-4837. doi: 10.1016/j.bmcl.2015.06.066. Epub 2015 Jun 23. Bioorg Med Chem Lett. 2015. PMID: 26144347 Free PMC article.

7

Multiparametric High-Content Assays to Measure Cell Health and Oxidative Damage as a Model for Drug-Induced Liver Injury.

Pohan G, Espinosa JA, Chen S, Ang KK, Arkin MR, Markossian S. Pohan G, et al. Curr Protoc Chem Biol. 2020 Dec;12(4):e90. doi: 10.1002/cpch.90. Curr Protoc Chem Biol. 2020. PMID: 33315311 Free PMC article.

8

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery.

Chen S, Suzuki BM, Dohrmann J, Singh R, Arkin MR, Caffrey CR. Chen S, et al. Commun Biol. 2020 Dec 21;3(1):747. doi: 10.1038/s42003-020-01402-5. Commun Biol. 2020. PMID: 33349640 Free PMC article.

9

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit.

De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. De Muylder G, et al. PLoS Negl Trop Dis. 2011 Jul;5(7):e1253. doi: 10.1371/journal.pntd.0001253. Epub 2011 Jul 19. PLoS Negl Trop Dis. 2011. PMID: 21811648 Free PMC article.

10

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.

Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Gunatilleke SS, et al. PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31. PLoS Negl Trop Dis. 2012. PMID: 22860142 Free PMC article.

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