Testa JR - Search Results

1

Preclinical Efficacy for AKT Targeting in Clear Cell Carcinoma of the Ovary.

Sasano T, Mabuchi S, Kuroda H, Kawano M, Matsumoto Y, Takahashi R, Hisamatsu T, Sawada K, Hashimoto K, Isobe A, Testa JR, Kimura T. Sasano T, et al. Among authors: testa jr. Mol Cancer Res. 2015 Apr;13(4):795-806. doi: 10.1158/1541-7786.MCR-14-0314. Epub 2014 Dec 17. Mol Cancer Res. 2015. PMID: 25519148 Free PMC article.

2

Amplification of the ATP-binding cassette 2 transporter gene is functionally linked with enhanced efflux of estramustine in ovarian carcinoma cells.

Laing NM, Belinsky MG, Kruh GD, Bell DW, Boyd JT, Barone L, Testa JR, Tew KD. Laing NM, et al. Among authors: testa jr. Cancer Res. 1998 Apr 1;58(7):1332-7. Cancer Res. 1998. PMID: 9537224

3

The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel.

Mitsuuchi Y, Johnson SW, Selvakumaran M, Williams SJ, Hamilton TC, Testa JR. Mitsuuchi Y, et al. Among authors: testa jr. Cancer Res. 2000 Oct 1;60(19):5390-4. Cancer Res. 2000. PMID: 11034077

4

AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells.

Tanno S, Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. Tanno S, et al. Among authors: testa jr. Cancer Res. 2001 Jan 15;61(2):589-93. Cancer Res. 2001. PMID: 11212254

5

A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities.

Bellacosa A, Testa JR, Moore R, Larue L. Bellacosa A, et al. Among authors: testa jr. Cancer Biol Ther. 2004 Mar;3(3):268-75. doi: 10.4161/cbt.3.3.703. Epub 2004 Mar 11. Cancer Biol Ther. 2004. PMID: 15034304 Free article. Review.

6

Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance.

Tanno S, Yanagawa N, Habiro A, Koizumi K, Nakano Y, Osanai M, Mizukami Y, Okumura T, Testa JR, Kohgo Y. Tanno S, et al. Among authors: testa jr. Cancer Res. 2004 May 15;64(10):3486-90. doi: 10.1158/0008-5472.CAN-03-1788. Cancer Res. 2004. PMID: 15150102

7

AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth.

Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK, Testa JR. Altomare DA, et al. Among authors: testa jr. Oncogene. 2004 Jul 29;23(34):5853-7. doi: 10.1038/sj.onc.1207721. Oncogene. 2004. PMID: 15208673

8

Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions.

Balsara BR, Pei J, Mitsuuchi Y, Page R, Klein-Szanto A, Wang H, Unger M, Testa JR. Balsara BR, et al. Among authors: testa jr. Carcinogenesis. 2004 Nov;25(11):2053-9. doi: 10.1093/carcin/bgh226. Epub 2004 Jul 7. Carcinogenesis. 2004. PMID: 15240509

9

Inhibition of inhibitor of nuclear factor-kappaB phosphorylation increases the efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

Mabuchi S, Ohmichi M, Nishio Y, Hayasaka T, Kimura A, Ohta T, Kawagoe J, Takahashi K, Yada-Hashimoto N, Seino-Noda H, Sakata M, Motoyama T, Kurachi H, Testa JR, Tasaka K, Murata Y. Mabuchi S, et al. Among authors: testa jr. Clin Cancer Res. 2004 Nov 15;10(22):7645-54. doi: 10.1158/1078-0432.CCR-04-0958. Clin Cancer Res. 2004. PMID: 15569997

10

Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.

Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A, Testa JR. Wang HQ, et al. Among authors: testa jr. Oncogene. 2005 May 19;24(22):3574-82. doi: 10.1038/sj.onc.1208463. Oncogene. 2005. PMID: 15806173

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