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The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (α-syn) toxicity to rat nigral neurons.
Salganik M, Sergeyev VG, Shinde V, Meyers CA, Gorbatyuk MS, Lin JH, Zolotukhin S, Gorbatyuk OS. Salganik M, et al. Among authors: zolotukhin s. Neurobiol Aging. 2015 Jun;36(6):2213-23. doi: 10.1016/j.neurobiolaging.2015.02.018. Epub 2015 Mar 5. Neurobiol Aging. 2015. PMID: 25863526 Free PMC article.
Biodistribution and safety of a single rAAV3B-AAT vector for silencing and replacement of alpha-1 antitrypsin in Cynomolgus macaques.
Blackwood M, Gruntman AM, Tang Q, Pires-Ferreira D, Reil D, Kondratov O, Marsic D, Zolotukhin S, Gernoux G, Keeler AM, Mueller C, Flotte TR. Blackwood M, et al. Among authors: zolotukhin s. Mol Ther Methods Clin Dev. 2024 Jan 30;32(1):101200. doi: 10.1016/j.omtm.2024.101200. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2024. PMID: 38445045 Free PMC article.
201 results