Bourdet DL - Search Results

1

Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.

Smith JA, Bourdet DL, Daniels OT, Ding YS, Gallezot JD, Henry S, Kim KH, Kshirsagar S, Martin WJ, Obedencio GP, Stangeland E, Tsuruda PR, Williams W, Carson RE, Patil ST. Smith JA, et al. Among authors: bourdet dl. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. doi: 10.1093/ijnp/pyu027. Int J Neuropsychopharmacol. 2014. PMID: 25522383 Free PMC article.

2

Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat.

Bourdet DL, Tsuruda PR, Obedencio GP, Smith JA. Bourdet DL, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):137-45. doi: 10.1124/jpet.111.188417. Epub 2012 Jan 10. J Pharmacol Exp Ther. 2012. PMID: 22235148

3

5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.

Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT. Shen F, et al. Among authors: bourdet dl. Neuropharmacology. 2011 Jul-Aug;61(1-2):69-79. doi: 10.1016/j.neuropharm.2011.02.026. Epub 2011 Mar 12. Neuropharmacology. 2011. PMID: 21392515

4

Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species.

Hardwick RN, Brassil P, Badagnani I, Perkins K, Obedencio GP, Kim AS, Conner MW, Bourdet DL, Harstad EB. Hardwick RN, et al. Among authors: bourdet dl. Toxicol Sci. 2022 Mar 28;186(2):323-337. doi: 10.1093/toxsci/kfac002. Toxicol Sci. 2022. PMID: 35134999 Free PMC article.

5

Pharmacokinetics of Ampreloxetine, a Norepinephrine Reuptake Inhibitor, in Healthy Subjects and Adults with Attention-Deficit/Hyperactive Disorder or Fibromyalgia Pain.

Kanodia J, Lo A, Baldwin RM, Graham RA, Bourdet DL. Kanodia J, et al. Among authors: bourdet dl. Clin Pharmacokinet. 2021 Jan;60(1):121-131. doi: 10.1007/s40262-020-00918-7. Clin Pharmacokinet. 2021. PMID: 32856281 Free PMC article.

6

Safety, Pharmacokinetics, and Pharmacodynamics of TD-0714, a Novel Potent Neprilysin Inhibitor in Healthy Adult and Elderly Subjects.

Kanodia J, Lo A, Baldwin RM, Colley K, Zhou K, Bourdet DL. Kanodia J, et al. Among authors: bourdet dl. Clin Transl Sci. 2020 Nov;13(6):1307-1315. doi: 10.1111/cts.12831. Epub 2020 Aug 18. Clin Transl Sci. 2020. PMID: 32506827 Free PMC article. Clinical Trial.

7

Pharmacokinetics and pharmacodynamics of ampreloxetine, a novel, selective norepinephrine reuptake inhibitor, in symptomatic neurogenic orthostatic hypotension.

Lo A, Norcliffe-Kaufmann L, Vickery R, Bourdet D, Kanodia J. Lo A, et al. Clin Auton Res. 2021 Jun;31(3):395-403. doi: 10.1007/s10286-021-00800-x. Epub 2021 Mar 29. Clin Auton Res. 2021. PMID: 33782836 Free PMC article.

8

Revefenacin, a Long-Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo- and Positive-Controlled Thorough QT Study.

Borin MT, Barnes CN, Darpo B, Pendyala S, Xue H, Bourdet DL. Borin MT, et al. Among authors: bourdet dl. Clin Pharmacol Drug Dev. 2020 Jan;9(1):130-139. doi: 10.1002/cpdd.732. Epub 2019 Aug 29. Clin Pharmacol Drug Dev. 2020. PMID: 31468714 Free PMC article. Clinical Trial.

9

Pharmacokinetics and safety of revefenacin in subjects with impaired renal or hepatic function.

Borin MT, Lo A, Barnes CN, Pendyala S, Bourdet DL. Borin MT, et al. Among authors: bourdet dl. Int J Chron Obstruct Pulmon Dis. 2019 Oct 8;14:2305-2318. doi: 10.2147/COPD.S203709. eCollection 2019. Int J Chron Obstruct Pulmon Dis. 2019. PMID: 31632000 Free PMC article.

10

Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of Its Major Metabolite.

Bourdet DL, Yeola S, Hegde SS, Colson PJ, Barnes CN, Borin MT. Bourdet DL, et al. Drug Metab Dispos. 2020 Dec;48(12):1312-1320. doi: 10.1124/dmd.120.000103. Epub 2020 Sep 25. Drug Metab Dispos. 2020. PMID: 32978223 Clinical Trial.

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