Smith JA - Search Results

1

Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.

Smith JA, Bourdet DL, Daniels OT, Ding YS, Gallezot JD, Henry S, Kim KH, Kshirsagar S, Martin WJ, Obedencio GP, Stangeland E, Tsuruda PR, Williams W, Carson RE, Patil ST. Smith JA, et al. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. doi: 10.1093/ijnp/pyu027. Int J Neuropsychopharmacol. 2014. PMID: 25522383 Free PMC article.

2

Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat.

Bourdet DL, Tsuruda PR, Obedencio GP, Smith JA. Bourdet DL, et al. Among authors: smith ja. J Pharmacol Exp Ther. 2012 Apr;341(1):137-45. doi: 10.1124/jpet.111.188417. Epub 2012 Jan 10. J Pharmacol Exp Ther. 2012. PMID: 22235148

3

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model.

Shen F, Tsuruda PR, Smith JA, Obedencio GP, Martin WJ. Shen F, et al. Among authors: smith ja. PLoS One. 2013 Sep 30;8(9):e74891. doi: 10.1371/journal.pone.0074891. eCollection 2013. PLoS One. 2013. PMID: 24098676 Free PMC article.

4

5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.

Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT. Shen F, et al. Among authors: smith ja. Neuropharmacology. 2011 Jul-Aug;61(1-2):69-79. doi: 10.1016/j.neuropharm.2011.02.026. Epub 2011 Mar 12. Neuropharmacology. 2011. PMID: 21392515

5

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships.

Van Orden LJ, Van Dyke PM, Saito DR, Church TJ, Chang R, Smith JA, Martin WJ, Jaw-Tsai S, Stangeland EL. Van Orden LJ, et al. Among authors: smith ja. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1456-61. doi: 10.1016/j.bmcl.2012.12.061. Epub 2012 Dec 22. Bioorg Med Chem Lett. 2013. PMID: 23347683

6

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters.

Tsuruda PR, Yung J, Martin WJ, Chang R, Mai N, Smith JA. Tsuruda PR, et al. Among authors: smith ja. J Pharmacol Toxicol Methods. 2010 Mar-Apr;61(2):192-204. doi: 10.1016/j.vascn.2009.12.003. Epub 2009 Dec 28. J Pharmacol Toxicol Methods. 2010. PMID: 20036748

7

The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Smith JA, Beattie DT, Marquess D, Shaw JP, Vickery RG, Humphrey PP. Smith JA, et al. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37. doi: 10.1007/s00210-008-0282-y. Epub 2008 Apr 16. Naunyn Schmiedebergs Arch Pharmacol. 2008. PMID: 18415081

8

Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.

Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum AA, Humphrey PP, Marquess DG, Shaw JP, Smith JA, Derek Turner S, Vickery RG. Long DD, et al. Among authors: smith ja. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4849-53. doi: 10.1016/j.bmcl.2012.05.034. Epub 2012 May 15. Bioorg Med Chem Lett. 2012. PMID: 22683222

9

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Beattie DT, Armstrong SR, Shaw JP, Marquess D, Sandlund C, Smith JA, Taylor JA, Humphrey PP. Beattie DT, et al. Among authors: smith ja. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47. doi: 10.1007/s00210-008-0281-z. Epub 2008 Apr 12. Naunyn Schmiedebergs Arch Pharmacol. 2008. PMID: 18408918

10

An in vitro investigation of the cardiovascular effects of the 5-HT(4) receptor selective agonists, velusetrag and TD-8954.

Beattie DT, Higgins DL, Ero MP, Amagasu SM, Vickery RG, Kersey K, Hopkins A, Smith JA. Beattie DT, et al. Among authors: smith ja. Vascul Pharmacol. 2013 Jan;58(1-2):150-6. doi: 10.1016/j.vph.2012.11.002. Epub 2012 Nov 29. Vascul Pharmacol. 2013. PMID: 23201772

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