Alessi DR - Search Results

1

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.

Perez-Oliva AB, Lachaud C, Szyniarowski P, Muñoz I, Macartney T, Hickson I, Rouse J, Alessi DR. Perez-Oliva AB, et al. Among authors: alessi dr. EMBO J. 2015 Feb 3;34(3):326-43. doi: 10.15252/embj.201489184. Epub 2014 Dec 23. EMBO J. 2015. PMID: 25538220 Free PMC article.

2

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM. Groom LA, et al. Among authors: alessi dr. EMBO J. 1996 Jul 15;15(14):3621-32. EMBO J. 1996. PMID: 8670865 Free PMC article.

3

Mechanism of activation of protein kinase B by insulin and IGF-1.

Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. Alessi DR, et al. EMBO J. 1996 Dec 2;15(23):6541-51. EMBO J. 1996. PMID: 8978681 Free PMC article.

4

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB.

Deak M, Clifton AD, Lucocq LM, Alessi DR. Deak M, et al. Among authors: alessi dr. EMBO J. 1998 Aug 3;17(15):4426-41. doi: 10.1093/emboj/17.15.4426. EMBO J. 1998. PMID: 9687510 Free PMC article.

5

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR. Biondi RM, et al. Among authors: alessi dr. EMBO J. 2001 Aug 15;20(16):4380-90. doi: 10.1093/emboj/20.16.4380. EMBO J. 2001. PMID: 11500365 Free PMC article.

6

Essential role of PDK1 in regulating cell size and development in mice.

Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR. Lawlor MA, et al. Among authors: alessi dr. EMBO J. 2002 Jul 15;21(14):3728-38. doi: 10.1093/emboj/cdf387. EMBO J. 2002. PMID: 12110585 Free PMC article.

7

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.

Collins BJ, Deak M, Arthur JS, Armit LJ, Alessi DR. Collins BJ, et al. Among authors: alessi dr. EMBO J. 2003 Aug 15;22(16):4202-11. doi: 10.1093/emboj/cdg407. EMBO J. 2003. PMID: 12912918 Free PMC article.

8

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.

Mora A, Davies AM, Bertrand L, Sharif I, Budas GR, Jovanović S, Mouton V, Kahn CR, Lucocq JM, Gray GA, Jovanović A, Alessi DR. Mora A, et al. Among authors: alessi dr. EMBO J. 2003 Sep 15;22(18):4666-76. doi: 10.1093/emboj/cdg469. EMBO J. 2003. PMID: 12970179 Free PMC article.

9

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. Boudeau J, et al. Among authors: alessi dr. EMBO J. 2003 Oct 1;22(19):5102-14. doi: 10.1093/emboj/cdg490. EMBO J. 2003. PMID: 14517248 Free PMC article.

10

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR. Lizcano JM, et al. Among authors: alessi dr. EMBO J. 2004 Feb 25;23(4):833-43. doi: 10.1038/sj.emboj.7600110. Epub 2004 Feb 19. EMBO J. 2004. PMID: 14976552 Free PMC article.

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