Park SW - Search Results

1

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.

Park SW, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D, Aldrich CC. Park SW, et al. Chem Biol. 2015 Jan 22;22(1):76-86. doi: 10.1016/j.chembiol.2014.11.012. Epub 2014 Dec 31. Chem Biol. 2015. PMID: 25556942 Free PMC article.

2

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.

Rhee KY, de Carvalho LP, Bryk R, Ehrt S, Marrero J, Park SW, Schnappinger D, Venugopal A, Nathan C. Rhee KY, et al. Among authors: park sw. Trends Microbiol. 2011 Jul;19(7):307-14. doi: 10.1016/j.tim.2011.03.008. Epub 2011 May 10. Trends Microbiol. 2011. PMID: 21561773 Free PMC article.

3

Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

Shi C, Geders TW, Park SW, Wilson DJ, Boshoff HI, Abayomi O, Barry CE 3rd, Schnappinger D, Finzel BC, Aldrich CC. Shi C, et al. Among authors: park sw. J Am Chem Soc. 2011 Nov 16;133(45):18194-201. doi: 10.1021/ja204036t. Epub 2011 Oct 24. J Am Chem Soc. 2011. PMID: 21988601 Free PMC article.

4

Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.

Dai R, Geders TW, Liu F, Park SW, Schnappinger D, Aldrich CC, Finzel BC. Dai R, et al. Among authors: park sw. J Med Chem. 2015 Jul 9;58(13):5208-17. doi: 10.1021/acs.jmedchem.5b00092. Epub 2015 Jun 24. J Med Chem. 2015. PMID: 26068403 Free PMC article.

5

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.

DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. DeJesus MA, et al. Among authors: park sw. mBio. 2017 Jan 17;8(1):e02133-16. doi: 10.1128/mBio.02133-16. mBio. 2017. PMID: 28096490 Free PMC article.

6

Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

Liu F, Dawadi S, Maize KM, Dai R, Park SW, Schnappinger D, Finzel BC, Aldrich CC. Liu F, et al. Among authors: park sw. J Med Chem. 2017 Jul 13;60(13):5507-5520. doi: 10.1021/acs.jmedchem.7b00189. Epub 2017 Jun 22. J Med Chem. 2017. PMID: 28594172 Free PMC article.

7

Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.

Xu W, DeJesus MA, Rücker N, Engelhart CA, Wright MG, Healy C, Lin K, Wang R, Park SW, Ioerger TR, Schnappinger D, Ehrt S. Xu W, et al. Among authors: park sw. Antimicrob Agents Chemother. 2017 Nov 22;61(12):e01334-17. doi: 10.1128/AAC.01334-17. Print 2017 Dec. Antimicrob Agents Chemother. 2017. PMID: 28893793 Free PMC article.

8

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.

Dawadi S, Boshoff HIM, Park SW, Schnappinger D, Aldrich CC. Dawadi S, et al. Among authors: park sw. ACS Med Chem Lett. 2018 Mar 16;9(4):386-391. doi: 10.1021/acsmedchemlett.8b00090. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670706 Free PMC article.

9

Targeting protein biotinylation enhances tuberculosis chemotherapy.

Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D. Tiwari D, et al. Among authors: park sw. Sci Transl Med. 2018 Apr 25;10(438):eaal1803. doi: 10.1126/scitranslmed.aal1803. Sci Transl Med. 2018. PMID: 29695454 Free PMC article.

10

Investigation of ( S)-(-)-Acidomycin: A Selective Antimycobacterial Natural Product That Inhibits Biotin Synthase.

Bockman MR, Engelhart CA, Cramer JD, Howe MD, Mishra NK, Zimmerman M, Larson P, Alvarez-Cabrera N, Park SW, Boshoff HIM, Bean JM, Young VG Jr, Ferguson DM, Dartois V, Jarrett JT, Schnappinger D, Aldrich CC. Bockman MR, et al. Among authors: park sw. ACS Infect Dis. 2019 Apr 12;5(4):598-617. doi: 10.1021/acsinfecdis.8b00345. Epub 2019 Feb 4. ACS Infect Dis. 2019. PMID: 30652474 Free PMC article.

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