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Page 1
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Fang S, et al. Among authors: liddle c. Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5. Nat Med. 2015. PMID: 25559344 Free PMC article.
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites.
Sonoda J, Chong LW, Downes M, Barish GD, Coulter S, Liddle C, Lee CH, Evans RM. Sonoda J, et al. Among authors: liddle c. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2198-203. doi: 10.1073/pnas.0409481102. Epub 2005 Jan 25. Proc Natl Acad Sci U S A. 2005. PMID: 15671183 Free PMC article.
Benefit of farnesoid X receptor inhibition in obstructive cholestasis.
Stedman C, Liddle C, Coulter S, Sonoda J, Alvarez JG, Evans RM, Downes M. Stedman C, et al. Among authors: liddle c. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11323-8. doi: 10.1073/pnas.0604772103. Epub 2006 Jul 14. Proc Natl Acad Sci U S A. 2006. PMID: 16844773 Free PMC article.
Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism.
Kacevska M, Downes MR, Sharma R, Evans RM, Clarke SJ, Liddle C, Robertson GR. Kacevska M, et al. Among authors: liddle c. Clin Cancer Res. 2011 May 15;17(10):3170-80. doi: 10.1158/1078-0432.CCR-10-3289. Epub 2011 Apr 15. Clin Cancer Res. 2011. PMID: 21498392 Free PMC article.
FXR and PXR: potential therapeutic targets in cholestasis.
Jonker JW, Liddle C, Downes M. Jonker JW, et al. Among authors: liddle c. J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):147-58. doi: 10.1016/j.jsbmb.2011.06.012. Epub 2011 Jul 20. J Steroid Biochem Mol Biol. 2012. PMID: 21801835 Free PMC article. Review.
248 results