Krainer AR - Search Results

1

Motor neuron cell-nonautonomous rescue of spinal muscular atrophy phenotypes in mild and severe transgenic mouse models.

Hua Y, Liu YH, Sahashi K, Rigo F, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Genes Dev. 2015 Feb 1;29(3):288-97. doi: 10.1101/gad.256644.114. Epub 2015 Jan 12. Genes Dev. 2015. PMID: 25583329 Free PMC article.

2

Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins.

Liu HX, Zhang M, Krainer AR. Liu HX, et al. Among authors: krainer ar. Genes Dev. 1998 Jul 1;12(13):1998-2012. doi: 10.1101/gad.12.13.1998. Genes Dev. 1998. PMID: 9649504 Free PMC article.

3

Pre-mRNA splicing in the absence of an SR protein RS domain.

Zhu J, Krainer AR. Zhu J, et al. Among authors: krainer ar. Genes Dev. 2000 Dec 15;14(24):3166-78. doi: 10.1101/gad.189500. Genes Dev. 2000. PMID: 11124808 Free PMC article.

4

Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1.

Cartegni L, Krainer AR. Cartegni L, et al. Among authors: krainer ar. Nat Genet. 2002 Apr;30(4):377-84. doi: 10.1038/ng854. Epub 2002 Mar 4. Nat Genet. 2002. PMID: 11925564

5

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

Cartegni L, Hastings ML, Calarco JA, de Stanchina E, Krainer AR. Cartegni L, et al. Among authors: krainer ar. Am J Hum Genet. 2006 Jan;78(1):63-77. doi: 10.1086/498853. Epub 2005 Nov 16. Am J Hum Genet. 2006. PMID: 16385450 Free PMC article.

6

Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon.

Hua Y, Vickers TA, Baker BF, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. PLoS Biol. 2007 Apr;5(4):e73. doi: 10.1371/journal.pbio.0050073. PLoS Biol. 2007. PMID: 17355180 Free PMC article.

7

Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice.

Hua Y, Vickers TA, Okunola HL, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Am J Hum Genet. 2008 Apr;82(4):834-48. doi: 10.1016/j.ajhg.2008.01.014. Epub 2008 Mar 27. Am J Hum Genet. 2008. PMID: 18371932 Free PMC article.

8

A positive modifier of spinal muscular atrophy in the SMN2 gene.

Prior TW, Krainer AR, Hua Y, Swoboda KJ, Snyder PC, Bridgeman SJ, Burghes AH, Kissel JT. Prior TW, et al. Among authors: krainer ar. Am J Hum Genet. 2009 Sep;85(3):408-13. doi: 10.1016/j.ajhg.2009.08.002. Epub 2009 Aug 27. Am J Hum Genet. 2009. PMID: 19716110 Free PMC article.

9

Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy.

Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Hastings ML, et al. Among authors: krainer ar. Sci Transl Med. 2009 Nov 4;1(5):5ra12. doi: 10.1126/scitranslmed.3000208. Sci Transl Med. 2009. PMID: 20161659 Free PMC article.

10

Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model.

Hua Y, Sahashi K, Hung G, Rigo F, Passini MA, Bennett CF, Krainer AR. Hua Y, et al. Among authors: krainer ar. Genes Dev. 2010 Aug 1;24(15):1634-44. doi: 10.1101/gad.1941310. Epub 2010 Jul 12. Genes Dev. 2010. PMID: 20624852 Free PMC article.

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