Yu CW - Search Results

1

A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.

Chang PT, Talekar RS, Kung FL, Chern TR, Huang CW, Ye QQ, Yang MY, Yu CW, Lai SY, Deore RR, Lin JH, Chen CS, Chen GS, Chern JW. Chang PT, et al. Among authors: yu cw. Neuropharmacology. 2015 May;92:146-57. doi: 10.1016/j.neuropharm.2015.01.004. Epub 2015 Jan 14. Neuropharmacology. 2015. PMID: 25596491

2

Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.

Khanwelkar RR, Chen GS, Wang HC, Yu CW, Huang CH, Lee O, Chen CH, Hwang CS, Ko CH, Chou NT, Lin MW, Wang LM, Chen YC, Hseu TH, Chang CN, Hsu HC, Lin HC, Shih YC, Chou SH, Tseng HW, Liu CP, Tu CM, Hu TL, Tsai YJ, Chern JW. Khanwelkar RR, et al. Among authors: yu cw. Bioorg Med Chem. 2010 Jul 1;18(13):4674-86. doi: 10.1016/j.bmc.2010.05.021. Epub 2010 May 12. Bioorg Med Chem. 2010. PMID: 20570526

3

Efficient microwave-assisted Pd-catalyzed hydroxylation of aryl chlorides in the presence of carbonate.

Yu CW, Chen GS, Huang CW, Chern JW. Yu CW, et al. Org Lett. 2012 Jul 20;14(14):3688-91. doi: 10.1021/ol301523q. Epub 2012 Jul 3. Org Lett. 2012. PMID: 22758780

4

Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.

Yu CW, Chang PT, Hsin LW, Chern JW. Yu CW, et al. J Med Chem. 2013 Sep 12;56(17):6775-91. doi: 10.1021/jm400564j. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23905680

5

A highly HDAC6-selective inhibitor acts as a fluorescent probe.

Ho YH, Wang KJ, Hung PY, Cheng YS, Liu JR, Fung ST, Liang PH, Chern JW, Yu CW. Ho YH, et al. Among authors: yu cw. Org Biomol Chem. 2018 Oct 31;16(42):7820-7832. doi: 10.1039/c8ob00966j. Org Biomol Chem. 2018. PMID: 30168823

6

Novel histone deacetylase inhibitors and embryo aggregation enhance cloned embryo development and ES cell derivation in pigs.

Siriboon C, Li TS, Yu CW, Chern JW, Ju JC. Siriboon C, et al. Among authors: yu cw. PLoS One. 2018 Sep 27;13(9):e0204588. doi: 10.1371/journal.pone.0204588. eCollection 2018. PLoS One. 2018. PMID: 30261020 Free PMC article.

7

Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.

Yu CW, Hung PY, Yang HT, Ho YH, Lai HY, Cheng YS, Chern JW. Yu CW, et al. J Med Chem. 2019 Jan 24;62(2):857-874. doi: 10.1021/acs.jmedchem.8b01590. Epub 2018 Dec 20. J Med Chem. 2019. PMID: 30525585

8

High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma.

Liu JR, Yu CW, Hung PY, Hsin LW, Chern JW. Liu JR, et al. Among authors: yu cw. Biochem Pharmacol. 2019 May;163:458-471. doi: 10.1016/j.bcp.2019.03.023. Epub 2019 Mar 15. Biochem Pharmacol. 2019. PMID: 30885763

9

Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.

Peng C, Li YH, Yu CW, Cheng ZH, Liu JR, Hsu JL, Hsin LW, Huang CT, Juan HF, Chern JW, Cheng YS. Peng C, et al. Among authors: yu cw. Bioorg Chem. 2021 May;110:104813. doi: 10.1016/j.bioorg.2021.104813. Epub 2021 Mar 10. Bioorg Chem. 2021. PMID: 33774493 Free article.

10

Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis.

Yu WC, Yeh TY, Ye CH, Chong PCT, Ho YH, So DK, Yap KY, Peng GR, Shao CH, Jagtap AD, Chern JW, Lin CS, Lin SP, Lin SL, Yu SH, Yu CW. Yu WC, et al. Among authors: yu cw, yu sh. J Med Chem. 2023 Aug 10;66(15):10528-10557. doi: 10.1021/acs.jmedchem.3c00644. Epub 2023 Jul 18. J Med Chem. 2023. PMID: 37463500

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