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Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Lau J, Bloch P, Schäffer L, Pettersson I, Spetzler J, Kofoed J, Madsen K, Knudsen LB, McGuire J, Steensgaard DB, Strauss HM, Gram DX, Knudsen SM, Nielsen FS, Thygesen P, Reedtz-Runge S, Kruse T. Lau J, et al. Among authors: pettersson i. J Med Chem. 2015 Sep 24;58(18):7370-80. doi: 10.1021/acs.jmedchem.5b00726. Epub 2015 Sep 11. J Med Chem. 2015. PMID: 26308095
SAXS-Guided Metadynamics.
Kimanius D, Pettersson I, Schluckebier G, Lindahl E, Andersson M. Kimanius D, et al. Among authors: pettersson i. J Chem Theory Comput. 2015 Jul 14;11(7):3491-8. doi: 10.1021/acs.jctc.5b00299. J Chem Theory Comput. 2015. PMID: 26575782
Large dimeric ligands with favorable pharmacokinetic properties and peroxisome proliferator-activated receptor agonist activity in vitro and in vivo.
Sauerberg P, Bury PS, Mogensen JP, Deussen HJ, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Svensson LA, Ynddal L, Wulff EM, Jeppesen L. Sauerberg P, et al. Among authors: pettersson i. J Med Chem. 2003 Nov 6;46(23):4883-94. doi: 10.1021/jm0309046. J Med Chem. 2003. PMID: 14584939
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
Mogensen JP, Jeppesen L, Bury PS, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Mortensen SB, Svensson LA, Wassermann K, Wulff EM, Ynddal L, Sauerberg P. Mogensen JP, et al. Among authors: pettersson i. Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60. doi: 10.1016/s0960-894x(02)00881-8. Bioorg Med Chem Lett. 2003. PMID: 12482434
118 results