Zerwes HG - Search Results

1

Discovery and profiling of a selective and efficacious Syk inhibitor.

Thoma G, Smith AB, van Eis MJ, Vangrevelinghe E, Blanz J, Aichholz R, Littlewood-Evans A, Lee CC, Liu H, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. J Med Chem. 2015 Feb 26;58(4):1950-63. doi: 10.1021/jm5018863. Epub 2015 Feb 9. J Med Chem. 2015. PMID: 25633741

2

Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.

Thoma G, Nuninger F, Falchetto R, Hermes E, Tavares GA, Vangrevelinghe E, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. J Med Chem. 2011 Jan 13;54(1):284-8. doi: 10.1021/jm101157q. Epub 2010 Dec 14. J Med Chem. 2011. PMID: 21155605

3

Syk inhibitors with high potency in presence of blood.

Thoma G, Blanz J, Bühlmayer P, Drückes P, Kittelmann M, Smith AB, van Eis M, Vangrevelinghe E, Zerwes HG, Che JJ, He X, Jin Y, Lee CC, Michellys PY, Uno T, Liu H. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2014 May 15;24(10):2278-82. doi: 10.1016/j.bmcl.2014.03.075. Epub 2014 Apr 3. Bioorg Med Chem Lett. 2014. PMID: 24726806

4

Selective inhibitors of the Janus kinase Jak3--Are they effective?

Thoma G, Drückes P, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4617-4621. doi: 10.1016/j.bmcl.2014.08.046. Epub 2014 Aug 28. Bioorg Med Chem Lett. 2014. PMID: 25217444 Review.

5

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.

Thoma G, Veenstra S, Strang R, Blanz J, Vangrevelinghe E, Berghausen J, Lee CC, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4642-7. doi: 10.1016/j.bmcl.2015.08.037. Epub 2015 Aug 18. Bioorg Med Chem Lett. 2015. PMID: 26320624

6

Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.

Thoma G, Streiff MB, Kovarik J, Glickman F, Wagner T, Beerli C, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. J Med Chem. 2008 Dec 25;51(24):7915-20. doi: 10.1021/jm801065q. J Med Chem. 2008. PMID: 19053768

7

Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK.

Waelchli R, Bollbuck B, Bruns C, Buhl T, Eder J, Feifel R, Hersperger R, Janser P, Revesz L, Zerwes HG, Schlapbach A. Waelchli R, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12. doi: 10.1016/j.bmcl.2005.09.035. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236504

8

Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors.

Haan C, Rolvering C, Raulf F, Kapp M, Drückes P, Thoma G, Behrmann I, Zerwes HG. Haan C, et al. Among authors: zerwes hg. Chem Biol. 2011 Mar 25;18(3):314-23. doi: 10.1016/j.chembiol.2011.01.012. Chem Biol. 2011. PMID: 21439476

9

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.

Schuler W, Sedrani R, Cottens S, Häberlin B, Schulz M, Schuurman HJ, Zenke G, Zerwes HG, Schreier MH. Schuler W, et al. Among authors: zerwes hg. Transplantation. 1997 Jul 15;64(1):36-42. doi: 10.1097/00007890-199707150-00008. Transplantation. 1997. PMID: 9233698

10

Two-step binding mechanism of fibrinogen to alpha IIb beta 3 integrin reconstituted into planar lipid bilayers.

Müller B, Zerwes HG, Tangemann K, Peter J, Engel J. Müller B, et al. Among authors: zerwes hg. J Biol Chem. 1993 Mar 25;268(9):6800-8. J Biol Chem. 1993. PMID: 8454652 Free article.

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