Workman P - Search Results

1

Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J. Mallinger A, et al. Among authors: workman p. J Med Chem. 2015 Feb 26;58(4):1717-35. doi: 10.1021/jm501436m. Epub 2015 Feb 13. J Med Chem. 2015. PMID: 25680029 Free PMC article.

2

Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

Clarke PA, Hostein I, Banerji U, Stefano FD, Maloney A, Walton M, Judson I, Workman P. Clarke PA, et al. Among authors: workman p. Oncogene. 2000 Aug 24;19(36):4125-33. doi: 10.1038/sj.onc.1203753. Oncogene. 2000. PMID: 10962573

3

Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.

Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Sharp SY, et al. Among authors: workman p. Mol Pharmacol. 2000 Nov;58(5):1146-55. doi: 10.1124/mol.58.5.1146. Mol Pharmacol. 2000. PMID: 11040064

4

Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.

Hostein I, Robertson D, DiStefano F, Workman P, Clarke PA. Hostein I, et al. Among authors: workman p. Cancer Res. 2001 May 15;61(10):4003-9. Cancer Res. 2001. PMID: 11358818

5

Innovative cancer drug targets: genomics, transcriptomics and clinomics.

Workman P, Clarke PA. Workman P, et al. Expert Opin Pharmacother. 2001 Jun;2(6):911-5. doi: 10.1517/14656566.2.6.911. Expert Opin Pharmacother. 2001. PMID: 11585007 No abstract available.

6

Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.

Smith V, Raynaud F, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Mol Pharmacol. 2001 Nov;60(5):885-93. doi: 10.1124/mol.60.5.885. Mol Pharmacol. 2001. PMID: 11641415

7

Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.

Kelland LR, Smith V, Valenti M, Patterson L, Clarke PA, Detre S, End D, Howes AJ, Dowsett M, Workman P, Johnston SR. Kelland LR, et al. Among authors: workman p. Clin Cancer Res. 2001 Nov;7(11):3544-50. Clin Cancer Res. 2001. PMID: 11705875

8

Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential.

Clarke PA, te Poele R, Wooster R, Workman P. Clarke PA, et al. Among authors: workman p. Biochem Pharmacol. 2001 Nov 15;62(10):1311-36. doi: 10.1016/s0006-2952(01)00785-7. Biochem Pharmacol. 2001. PMID: 11709192 Review.

9

Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.

Seddon BM, Maxwell RJ, Honess DJ, Grimshaw R, Raynaud F, Tozer GM, Workman P. Seddon BM, et al. Among authors: workman p. Clin Cancer Res. 2002 Jul;8(7):2323-35. Clin Cancer Res. 2002. PMID: 12114437

10

ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin.

Smith V, Hobbs S, Court W, Eccles S, Workman P, Kelland LR. Smith V, et al. Among authors: workman p. Anticancer Res. 2002 Jul-Aug;22(4):1993-9. Anticancer Res. 2002. PMID: 12174876

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