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Aneuploidy drives genomic instability in yeast.
Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, Brito IL, Hiraoka Y, Niwa O, Amon A. Sheltzer JM, et al. Science. 2011 Aug 19;333(6045):1026-30. doi: 10.1126/science.1206412. Science. 2011. PMID: 21852501 Free PMC article.
Transcriptional consequences of aneuploidy.
Sheltzer JM, Torres EM, Dunham MJ, Amon A. Sheltzer JM, et al. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12644-9. doi: 10.1073/pnas.1209227109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802626 Free PMC article.
Single-chromosome Gains Commonly Function as Tumor Suppressors.
Sheltzer JM, Ko JH, Replogle JM, Habibe Burgos NC, Chung ES, Meehl CM, Sayles NM, Passerini V, Storchova Z, Amon A. Sheltzer JM, et al. Cancer Cell. 2017 Feb 13;31(2):240-255. doi: 10.1016/j.ccell.2016.12.004. Epub 2017 Jan 12. Cancer Cell. 2017. PMID: 28089890 Free PMC article.
Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.
Replogle JM, Zhou W, Amaro AE, McFarland JM, Villalobos-Ortiz M, Ryan J, Letai A, Yilmaz O, Sheltzer J, Lippard SJ, Ben-David U, Amon A. Replogle JM, et al. Among authors: sheltzer j. Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30566-30576. doi: 10.1073/pnas.2009506117. Epub 2020 Nov 17. Proc Natl Acad Sci U S A. 2020. PMID: 33203674 Free PMC article.
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies.
Lukow DA, Sausville EL, Suri P, Chunduri NK, Wieland A, Leu J, Smith JC, Girish V, Kumar AA, Kendall J, Wang Z, Storchova Z, Sheltzer JM. Lukow DA, et al. Among authors: sheltzer jm. Dev Cell. 2021 Sep 13;56(17):2427-2439.e4. doi: 10.1016/j.devcel.2021.07.009. Epub 2021 Aug 4. Dev Cell. 2021. PMID: 34352222 Free PMC article.
43 results