Richardson DR - Search Results

1

Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).

Jansson PJ, Yamagishi T, Arvind A, Seebacher N, Gutierrez E, Stacy A, Maleki S, Sharp D, Sahni S, Richardson DR. Jansson PJ, et al. Among authors: richardson dr. J Biol Chem. 2015 Apr 10;290(15):9588-603. doi: 10.1074/jbc.M114.631283. Epub 2015 Feb 26. J Biol Chem. 2015. PMID: 25720491 Free PMC article.

2

Nitrogen monoxide (no) and glucose: unexpected links between energy metabolism and no-mediated iron mobilization from cells.

Watts RN, Richardson DR. Watts RN, et al. Among authors: richardson dr. J Biol Chem. 2001 Feb 16;276(7):4724-32. doi: 10.1074/jbc.M006318200. Epub 2000 Nov 14. J Biol Chem. 2001. PMID: 11078730 Free article.

3

Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.

Watts RN, Hawkins C, Ponka P, Richardson DR. Watts RN, et al. Among authors: richardson dr. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7670-5. doi: 10.1073/pnas.0602515103. Epub 2006 May 5. Proc Natl Acad Sci U S A. 2006. PMID: 16679408 Free PMC article.

4

A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics.

Whitnall M, Howard J, Ponka P, Richardson DR. Whitnall M, et al. Among authors: richardson dr. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6. doi: 10.1073/pnas.0604979103. Epub 2006 Sep 26. Proc Natl Acad Sci U S A. 2006. PMID: 17003122 Free PMC article.

5

Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.

Kalinowski DS, Yu Y, Sharpe PC, Islam M, Liao YT, Lovejoy DB, Kumar N, Bernhardt PV, Richardson DR. Kalinowski DS, et al. Among authors: richardson dr. J Med Chem. 2007 Jul 26;50(15):3716-29. doi: 10.1021/jm070445z. Epub 2007 Jun 30. J Med Chem. 2007. PMID: 17602603

6

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

Richardson DR, Kalinowski DS, Lau S, Jansson PJ, Lovejoy DB. Richardson DR, et al. Biochim Biophys Acta. 2009 Jul;1790(7):702-17. doi: 10.1016/j.bbagen.2008.04.003. Epub 2008 Apr 27. Biochim Biophys Acta. 2009. PMID: 18485918 Review.

7

Antitumor activity and mechanism of action of the iron chelator, Dp44mT, against leukemic cells.

Noulsri E, Richardson DR, Lerdwana S, Fucharoen S, Yamagishi T, Kalinowski DS, Pattanapanyasat K. Noulsri E, et al. Among authors: richardson dr. Am J Hematol. 2009 Mar;84(3):170-6. doi: 10.1002/ajh.21350. Am J Hematol. 2009. PMID: 19140186 Free article.

8

The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity.

Mladĕnka P, Kalinowski DS, Haskova P, Bobrovová Z, Hrdina R, Simůnek T, Nachtigal P, Semecký V, Vávrová J, Holeckova M, Palicka V, Mazurová Y, Jansson PJ, Richardson DR. Mladĕnka P, et al. Among authors: richardson dr. Chem Res Toxicol. 2009 Jan;22(1):208-17. doi: 10.1021/tx800331j. Chem Res Toxicol. 2009. PMID: 19172757

9

2-Acetylpyridine thiosemicarbazones are potent iron chelators and antiproliferative agents: redox activity, iron complexation and characterization of their antitumor activity.

Richardson DR, Kalinowski DS, Richardson V, Sharpe PC, Lovejoy DB, Islam M, Bernhardt PV. Richardson DR, et al. Among authors: richardson v. J Med Chem. 2009 Mar 12;52(5):1459-70. doi: 10.1021/jm801585u. J Med Chem. 2009. PMID: 19216562

10

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

Yu Y, Kalinowski DS, Kovacevic Z, Siafakas AR, Jansson PJ, Stefani C, Lovejoy DB, Sharpe PC, Bernhardt PV, Richardson DR. Yu Y, et al. Among authors: richardson dr. J Med Chem. 2009 Sep 10;52(17):5271-94. doi: 10.1021/jm900552r. J Med Chem. 2009. PMID: 19601577 Review. No abstract available.

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