Smith DF - Search Results

1

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.

Wright MH, Paape D, Storck EM, Serwa RA, Smith DF, Tate EW. Wright MH, et al. Among authors: smith df. Chem Biol. 2015 Mar 19;22(3):342-54. doi: 10.1016/j.chembiol.2015.01.003. Epub 2015 Feb 26. Chem Biol. 2015. PMID: 25728269 Free PMC article.

2

N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.

Brannigan JA, Smith BA, Yu Z, Brzozowski AM, Hodgkinson MR, Maroof A, Price HP, Meier F, Leatherbarrow RJ, Tate EW, Smith DF, Wilkinson AJ. Brannigan JA, et al. Among authors: smith ba, smith df. J Mol Biol. 2010 Mar 5;396(4):985-99. doi: 10.1016/j.jmb.2009.12.032. Epub 2009 Dec 28. J Mol Biol. 2010. PMID: 20036251 Free PMC article.

3

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Hutton JA, et al. Among authors: smith df. J Med Chem. 2014 Oct 23;57(20):8664-70. doi: 10.1021/jm5011397. Epub 2014 Oct 1. J Med Chem. 2014. PMID: 25238611 Free PMC article.

4

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF. Paape D, et al. Among authors: smith df. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3363. doi: 10.1371/journal.pntd.0003363. eCollection 2014 Dec. PLoS Negl Trop Dis. 2014. PMID: 25522361 Free PMC article.

5

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Rackham MD, et al. Among authors: smith df. Medchemcomm. 2015 Oct 8;6(10):1761-1766. doi: 10.1039/c5md00241a. Epub 2015 Aug 19. Medchemcomm. 2015. PMID: 26962429 Free PMC article.

6

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Paape D, Prendergast CT, Price HP, Doehl JSP, Smith DF. Paape D, et al. Among authors: smith df. Parasit Vectors. 2020 Mar 14;13(1):132. doi: 10.1186/s13071-020-3999-1. Parasit Vectors. 2020. PMID: 32171322 Free PMC article.

7

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

Bell AS, Yu Z, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Bell AS, et al. Among authors: smith df. J Med Chem. 2020 Jul 23;63(14):7740-7765. doi: 10.1021/acs.jmedchem.0c00570. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32575985 Free PMC article.

8

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF. Bowyer PW, et al. Among authors: smith df. Biochem J. 2007 Dec 1;408(2):173-80. doi: 10.1042/BJ20070692. Biochem J. 2007. PMID: 17714074 Free PMC article.

9

N-myristoyltransferase: a prospective drug target for protozoan parasites.

Bowyer PW, Tate EW, Leatherbarrow RJ, Holder AA, Smith DF, Brown KA. Bowyer PW, et al. Among authors: smith df. ChemMedChem. 2008 Mar;3(3):402-8. doi: 10.1002/cmdc.200700301. ChemMedChem. 2008. PMID: 18324715 Review. No abstract available.

10

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. Bell AS, et al. Among authors: smith df. PLoS Negl Trop Dis. 2012;6(4):e1625. doi: 10.1371/journal.pntd.0001625. Epub 2012 Apr 24. PLoS Negl Trop Dis. 2012. PMID: 22545171 Free PMC article.

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