Hawkins L - Search Results

1

Design and preclinical characterization of a novel vaccine adjuvant formulation consisting of a synthetic TLR4 agonist in a thermoreversible squalene emulsion.

Haensler J, Probeck P, Su J, Piras F, Dalençon F, Cotte JF, Chambon V, Iqbal SM, Hawkins L, Burdin N. Haensler J, et al. Among authors: hawkins l. Int J Pharm. 2015;486(1-2):99-111. doi: 10.1016/j.ijpharm.2015.03.028. Epub 2015 Mar 17. Int J Pharm. 2015. PMID: 25794609

2

E6020: a synthetic Toll-like receptor 4 agonist as a vaccine adjuvant.

Ishizaka ST, Hawkins LD. Ishizaka ST, et al. Expert Rev Vaccines. 2007 Oct;6(5):773-84. doi: 10.1586/14760584.6.5.773. Expert Rev Vaccines. 2007. PMID: 17931157 Free article. Review.

3

MF59 oil-in-water emulsion in combination with a synthetic TLR4 agonist (E6020) is a potent adjuvant for a combination Meningococcus vaccine.

Singh M, Kazzaz J, Ugozzoli M, Baudner B, Pizza M, Giuliani M, Hawkins LD, Otten G, O'Hagan DT. Singh M, et al. Hum Vaccin Immunother. 2012 Apr;8(4):486-90. doi: 10.4161/hv.19229. Hum Vaccin Immunother. 2012. PMID: 22832252 Free article.

4

Inhibition of endotoxin response by synthetic TLR4 antagonists.

Hawkins LD, Christ WJ, Rossignol DP. Hawkins LD, et al. Curr Top Med Chem. 2004;4(11):1147-71. doi: 10.2174/1568026043388123. Curr Top Med Chem. 2004. PMID: 15279606 Review.

5

MF59 emulsion is an effective delivery system for a synthetic TLR4 agonist (E6020).

Baudner BC, Ronconi V, Casini D, Tortoli M, Kazzaz J, Singh M, Hawkins LD, Wack A, O'Hagan DT. Baudner BC, et al. Pharm Res. 2009 Jun;26(6):1477-85. doi: 10.1007/s11095-009-9859-5. Epub 2009 Mar 3. Pharm Res. 2009. PMID: 19255727

6

E6020, a TLR4 Agonist Adjuvant, Enhances Both Antibody Titers and Isotype Switching in Response to Immunization with Hapten-Protein Antigens and Is Diminished in Mice with TLR4 Signaling Insufficiency.

Gopalakrishnan A, Richard K, Wahid R, Harley R, Sztein MB, Hawkins LD, Vogel SN. Gopalakrishnan A, et al. J Immunol. 2022 Nov 15;209(10):1950-1959. doi: 10.4049/jimmunol.2200495. J Immunol. 2022. PMID: 36426935 Free PMC article.

7

A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity.

Hawkins LD, Ishizaka ST, McGuinness P, Zhang H, Gavin W, DeCosta B, Meng Z, Yang H, Mullarkey M, Young DW, Yang H, Rossignol DP, Nault A, Rose J, Przetak M, Chow JC, Gusovsky F. Hawkins LD, et al. J Pharmacol Exp Ther. 2002 Feb;300(2):655-61. doi: 10.1124/jpet.300.2.655. J Pharmacol Exp Ther. 2002. PMID: 11805229 Clinical Trial.

8

Synthetic Toll-like receptor 4 agonist enhances vaccine efficacy in an experimental model of toxic shock syndrome.

Morefield GL, Hawkins LD, Ishizaka ST, Kissner TL, Ulrich RG. Morefield GL, et al. Among authors: hawkins ld. Clin Vaccine Immunol. 2007 Nov;14(11):1499-504. doi: 10.1128/CVI.00153-07. Epub 2007 Aug 22. Clin Vaccine Immunol. 2007. PMID: 17715328 Free PMC article.

9

Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant.

Arora R, Haile CN, Kosten TA, Wu Y, Ramakrishnan M, Hawkins LD, Orson FM, Kosten TR. Arora R, et al. Am J Addict. 2019 Feb;28(2):119-126. doi: 10.1111/ajad.12867. Epub 2019 Jan 31. Am J Addict. 2019. PMID: 30701618

10

Anti-endotoxin activity of a novel synthetic lipid A analog.

Kawata T, Bristol JR, Rose JR, Rossignol DP, Christ WJ, Asano O, Dubuc GR, Gavin WE, Hawkins LD, Kishi Y, et al. Kawata T, et al. Among authors: hawkins ld. Prog Clin Biol Res. 1995;392:499-509. Prog Clin Biol Res. 1995. PMID: 8524958

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