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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.
Brown NG, VanderLinden R, Watson ER, Qiao R, Grace CR, Yamaguchi M, Weissmann F, Frye JJ, Dube P, Ei Cho S, Actis ML, Rodrigues P, Fujii N, Peters JM, Stark H, Schulman BA. Brown NG, et al. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5272-9. doi: 10.1073/pnas.1504161112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825779 Free PMC article.
APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.
Uzunova K, Dye BT, Schutz H, Ladurner R, Petzold G, Toyoda Y, Jarvis MA, Brown NG, Poser I, Novatchkova M, Mechtler K, Hyman AA, Stark H, Schulman BA, Peters JM. Uzunova K, et al. Among authors: brown ng. Nat Struct Mol Biol. 2012 Nov;19(11):1116-23. doi: 10.1038/nsmb.2412. Epub 2012 Sep 24. Nat Struct Mol Biol. 2012. PMID: 23007861 Free PMC article.
Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.
Brown NG, Watson ER, Weissmann F, Jarvis MA, VanderLinden R, Grace CRR, Frye JJ, Qiao R, Dube P, Petzold G, Cho SE, Alsharif O, Bao J, Davidson IF, Zheng JJ, Nourse A, Kurinov I, Peters JM, Stark H, Schulman BA. Brown NG, et al. Mol Cell. 2014 Oct 23;56(2):246-260. doi: 10.1016/j.molcel.2014.09.009. Epub 2014 Oct 9. Mol Cell. 2014. PMID: 25306923 Free PMC article.
Measuring APC/C-Dependent Ubiquitylation In Vitro.
Jarvis MA, Brown NG, Watson ER, VanderLinden R, Schulman BA, Peters JM. Jarvis MA, et al. Among authors: brown ng. Methods Mol Biol. 2016;1342:287-303. doi: 10.1007/978-1-4939-2957-3_18. Methods Mol Biol. 2016. PMID: 26254932 Free PMC article.
Mechanism of APC/CCDC20 activation by mitotic phosphorylation.
Qiao R, Weissmann F, Yamaguchi M, Brown NG, VanderLinden R, Imre R, Jarvis MA, Brunner MR, Davidson IF, Litos G, Haselbach D, Mechtler K, Stark H, Schulman BA, Peters JM. Qiao R, et al. Among authors: brown ng. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2570-8. doi: 10.1073/pnas.1604929113. Epub 2016 Apr 25. Proc Natl Acad Sci U S A. 2016. PMID: 27114510 Free PMC article.
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA. Brown NG, et al. Cell. 2016 Jun 2;165(6):1440-1453. doi: 10.1016/j.cell.2016.05.037. Cell. 2016. PMID: 27259151 Free PMC article.
89 results