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Epigenetic regulation by histone demethylases in hypoxia.
Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A. Hancock RL, et al. Epigenomics. 2015 Aug;7(5):791-811. doi: 10.2217/epi.15.24. Epub 2015 Apr 2. Epigenomics. 2015. PMID: 25832587 Review.
The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.
Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, Franz H, Sippl W, Lassmann S, Diederichs S, Schleicher E, Schofield CJ, Kawamura A, Schüle R, Jung M. Roatsch M, et al. Among authors: hancock rl. ACS Chem Biol. 2019 Aug 16;14(8):1737-1750. doi: 10.1021/acschembio.9b00289. Epub 2019 Jul 19. ACS Chem Biol. 2019. PMID: 31287655
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinović J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ. Abboud MI, et al. Among authors: hancock rl. Chem Commun (Camb). 2018 Mar 28;54(25):3130-3133. doi: 10.1039/c8cc00387d. Epub 2018 Mar 9. Chem Commun (Camb). 2018. PMID: 29522057 Free PMC article.
Targeting Protein-Protein Interactions in the HIF System.
Wilkins SE, Abboud MI, Hancock RL, Schofield CJ. Wilkins SE, et al. Among authors: hancock rl. ChemMedChem. 2016 Apr 19;11(8):773-86. doi: 10.1002/cmdc.201600012. Epub 2016 Mar 21. ChemMedChem. 2016. PMID: 26997519 Free PMC article. Review.
96 results