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Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N. Chen SW, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8. Proc Natl Acad Sci U S A. 2015. PMID: 25855634 Free PMC article.
Characterization of the nanoscale properties of individual amyloid fibrils.
Smith JF, Knowles TP, Dobson CM, Macphee CE, Welland ME. Smith JF, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15806-11. doi: 10.1073/pnas.0604035103. Epub 2006 Oct 12. Proc Natl Acad Sci U S A. 2006. PMID: 17038504 Free PMC article.
Observation of spatial propagation of amyloid assembly from single nuclei.
Knowles TP, White DA, Abate AR, Agresti JJ, Cohen SI, Sperling RA, De Genst EJ, Dobson CM, Weitz DA. Knowles TP, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14746-51. doi: 10.1073/pnas.1105555108. Epub 2011 Aug 26. Proc Natl Acad Sci U S A. 2011. PMID: 21876182 Free PMC article.
Direct observation of the interconversion of normal and toxic forms of α-synuclein.
Cremades N, Cohen SI, Deas E, Abramov AY, Chen AY, Orte A, Sandal M, Clarke RW, Dunne P, Aprile FA, Bertoncini CW, Wood NW, Knowles TP, Dobson CM, Klenerman D. Cremades N, et al. Among authors: dobson cm. Cell. 2012 May 25;149(5):1048-59. doi: 10.1016/j.cell.2012.03.037. Cell. 2012. PMID: 22632969 Free PMC article.
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
Deas E, Cremades N, Angelova PR, Ludtmann MH, Yao Z, Chen S, Horrocks MH, Banushi B, Little D, Devine MJ, Gissen P, Klenerman D, Dobson CM, Wood NW, Gandhi S, Abramov AY. Deas E, et al. Among authors: dobson cm. Antioxid Redox Signal. 2016 Mar 1;24(7):376-91. doi: 10.1089/ars.2015.6343. Epub 2016 Feb 1. Antioxid Redox Signal. 2016. PMID: 26564470 Free PMC article.
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D. Iljina M, et al. Among authors: dobson cm. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1206-15. doi: 10.1073/pnas.1524128113. Epub 2016 Feb 16. Proc Natl Acad Sci U S A. 2016. PMID: 26884195 Free PMC article.
804 results