Griffin RJ - Search Results

1

Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases.

Miller DC, Carbain B, Beale GS, Alhasan SF, Reeves HL, Baisch U, Newell DR, Golding BT, Griffin RJ. Miller DC, et al. Among authors: griffin rj. Org Biomol Chem. 2015 May 14;13(18):5279-84. doi: 10.1039/c5ob00211g. Org Biomol Chem. 2015. PMID: 25858034

2

Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2.

Marchetti F, Sayle KL, Bentley J, Clegg W, Curtin NJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Harrington RW, Mesguiche V, Newell DR, Noble ME, Parsons RJ, Pratt DJ, Wang LZ, Hardcastle IR. Marchetti F, et al. Among authors: griffin rj. Org Biomol Chem. 2007 May 21;5(10):1577-85. doi: 10.1039/b703241b. Epub 2007 Apr 23. Org Biomol Chem. 2007. PMID: 17571187

3

Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase.

Barbeau OR, Cano-Soumillac C, Griffin RJ, Hardcastle IR, Smith GC, Richardson C, Clegg W, Harrington RW, Golding BT. Barbeau OR, et al. Among authors: griffin rj. Org Biomol Chem. 2007 Aug 21;5(16):2670-7. doi: 10.1039/b705095j. Org Biomol Chem. 2007. PMID: 18019542

4

Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors.

Marchetti F, Cano C, Curtin NJ, Golding BT, Griffin RJ, Haggerty K, Newell DR, Parsons RJ, Payne SL, Wang LZ, Hardcastle IR. Marchetti F, et al. Among authors: griffin rj. Org Biomol Chem. 2010 May 21;8(10):2397-407. doi: 10.1039/b925481a. Epub 2010 Mar 18. Org Biomol Chem. 2010. PMID: 20448898

5

Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates.

Wong C, Griffin RJ, Hardcastle IR, Northen JS, Wang LZ, Golding BT. Wong C, et al. Among authors: griffin rj. Org Biomol Chem. 2010 May 21;8(10):2457-64. doi: 10.1039/b922717b. Epub 2010 Mar 24. Org Biomol Chem. 2010. PMID: 20448906

6

Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK).

Cano C, Golding BT, Haggerty K, Hardcastle IR, Peacock M, Griffin RJ. Cano C, et al. Among authors: griffin rj. Org Biomol Chem. 2010 Apr 21;8(8):1922-8. doi: 10.1039/b926245h. Org Biomol Chem. 2010. PMID: 20449499

7

Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure.

Rodriguez-Aristegui S, Clapham KM, Barrett L, Cano C, Desage-El Murr M, Griffin RJ, Hardcastle IR, Payne SL, Rennison T, Richardson C, Golding BT. Rodriguez-Aristegui S, et al. Among authors: griffin rj. Org Biomol Chem. 2011 Sep 7;9(17):6066-74. doi: 10.1039/c1ob05282a. Epub 2011 Jul 12. Org Biomol Chem. 2011. PMID: 21748189

8

Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.

Clapham KM, Rennison T, Jones G, Craven F, Bardos J, Golding BT, Griffin RJ, Haggerty K, Hardcastle IR, Thommes P, Ting A, Cano C. Clapham KM, et al. Among authors: griffin rj. Org Biomol Chem. 2012 Sep 7;10(33):6747-57. doi: 10.1039/c2ob26035b. Epub 2012 Jul 19. Org Biomol Chem. 2012. PMID: 22814419

9

Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups.

Reuillon T, Bertoli A, Griffin RJ, Miller DC, Golding BT. Reuillon T, et al. Among authors: griffin rj. Org Biomol Chem. 2012 Oct 7;10(37):7610-7. doi: 10.1039/c2ob26057c. Epub 2012 Aug 14. Org Biomol Chem. 2012. PMID: 22893112

10

Trifluoroethanol solvent facilitates selective N-7 methylation of purines.

Lebraud H, Cano C, Carbain B, Hardcastle IR, Harrington RW, Griffin RJ, Golding BT. Lebraud H, et al. Among authors: griffin rj. Org Biomol Chem. 2013 Mar 21;11(11):1874-8. doi: 10.1039/c3ob27473j. Epub 2013 Feb 4. Org Biomol Chem. 2013. PMID: 23381666

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