Sleiman SF - Search Results

1

Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.

Olson DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, Holson EB. Olson DE, et al. Among authors: sleiman sf. Chem Biol. 2015 Apr 23;22(4):439-445. doi: 10.1016/j.chembiol.2015.03.014. Epub 2015 Apr 16. Chem Biol. 2015. PMID: 25892200 Free PMC article.

2

Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition.

Sleiman SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J, Wagner FF, Basso M, Coppola G, Pinto JT, Holson EB, Ratan RR. Sleiman SF, et al. J Neurosci. 2014 Oct 22;34(43):14328-37. doi: 10.1523/JNEUROSCI.1010-14.2014. J Neurosci. 2014. PMID: 25339746 Free PMC article.

3

Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions.

Sleiman SF, Basso M, Mahishi L, Kozikowski AP, Donohoe ME, Langley B, Ratan RR. Sleiman SF, et al. Expert Opin Investig Drugs. 2009 May;18(5):573-84. doi: 10.1517/13543780902810345. Expert Opin Investig Drugs. 2009. PMID: 19388875 Free PMC article. Review.

4

Histone Deacetylase Inhibitors and Mithramycin A Impact a Similar Neuroprotective Pathway at a Crossroad between Cancer and Neurodegeneration.

Sleiman SF, Berlin J, Basso M, Karuppagounder SS, Rohr J, Ratan RR. Sleiman SF, et al. Pharmaceuticals (Basel). 2011 Aug 22;4(8):1183-1195. doi: 10.3390/ph4081183. Pharmaceuticals (Basel). 2011. PMID: 22582024 Free PMC article.

5

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.

Speer RE, Karuppagounder SS, Basso M, Sleiman SF, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR. Speer RE, et al. Among authors: sleiman sf. Free Radic Biol Med. 2013 Sep;62:26-36. doi: 10.1016/j.freeradbiomed.2013.01.026. Epub 2013 Jan 31. Free Radic Biol Med. 2013. PMID: 23376032 Free PMC article. Review.

6

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate.

Sleiman SF, Henry J, Al-Haddad R, El Hayek L, Abou Haidar E, Stringer T, Ulja D, Karuppagounder SS, Holson EB, Ratan RR, Ninan I, Chao MV. Sleiman SF, et al. Elife. 2016 Jun 2;5:e15092. doi: 10.7554/eLife.15092. Elife. 2016. PMID: 27253067 Free PMC article.

7

Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.

Karnib N, El-Ghandour R, El Hayek L, Nasrallah P, Khalifeh M, Barmo N, Jabre V, Ibrahim P, Bilen M, Stephan JS, Holson EB, Ratan RR, Sleiman SF. Karnib N, et al. Among authors: sleiman sf. Neuropsychopharmacology. 2019 May;44(6):1152-1162. doi: 10.1038/s41386-019-0313-z. Epub 2019 Jan 8. Neuropsychopharmacology. 2019. PMID: 30647450 Free PMC article.

8

Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation.

Basso M, Berlin J, Xia L, Sleiman SF, Ko B, Haskew-Layton R, Kim E, Antonyak MA, Cerione RA, Iismaa SE, Willis D, Cho S, Ratan RR. Basso M, et al. Among authors: sleiman sf. J Neurosci. 2012 May 9;32(19):6561-9. doi: 10.1523/JNEUROSCI.3353-11.2012. J Neurosci. 2012. PMID: 22573678 Free PMC article.

9

Looking above but not beyond the genome for therapeutics in neurology and psychiatry: epigenetic proteins and RNAs find a new focus.

Basso M, Sleiman S, Ratan RR. Basso M, et al. Neurotherapeutics. 2013 Oct;10(4):551-5. doi: 10.1007/s13311-013-0225-2. Neurotherapeutics. 2013. PMID: 24092616 Free PMC article. No abstract available.

10

Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.

Aleyasin H, Karuppagounder SS, Kumar A, Sleiman S, Basso M, Ma T, Siddiq A, Chinta SJ, Brochier C, Langley B, Haskew-Layton R, Bane SL, Riggins GJ, Gazaryan I, Starkov AA, Andersen JK, Ratan RR. Aleyasin H, et al. Antioxid Redox Signal. 2015 Jan 10;22(2):121-34. doi: 10.1089/ars.2013.5595. Antioxid Redox Signal. 2015. PMID: 24766300 Free PMC article.

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