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Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
Suzuki R, Fukui T, Kishimoto M, Miyamoto S, Takahashi Y, Takeo M, Mitsuyama T, Sakaguchi Y, Uchida K, Nishio A, Okazaki K. Suzuki R, et al. Among authors: nishio a. J Crohns Colitis. 2015 Jul;9(7):565-74. doi: 10.1093/ecco-jcc/jjv073. Epub 2015 Apr 23. J Crohns Colitis. 2015. PMID: 25908723
The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis.
Fukui T, Kishimoto M, Nakajima A, Yamashina M, Nakayama S, Kusuda T, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K. Fukui T, et al. Among authors: nishio a. J Gastroenterol. 2011 Apr;46(4):456-68. doi: 10.1007/s00535-010-0364-8. Epub 2011 Jan 13. J Gastroenterol. 2011. PMID: 21229365
Phosphorylation of Smad2/3 at the specific linker threonine residue indicates slow-cycling esophageal stem-like cells before re-entry to the cell cycle.
Takahashi Y, Fukui T, Kishimoto M, Suzuki R, Mitsuyama T, Sumimoto K, Okazaki T, Sakao M, Sakaguchi Y, Yoshida K, Uchida K, Nishio A, Matsuzaki K, Okazaki K. Takahashi Y, et al. Among authors: nishio a. Dis Esophagus. 2016 Feb-Mar;29(2):107-15. doi: 10.1111/dote.12277. Epub 2014 Aug 29. Dis Esophagus. 2016. PMID: 25168378
551 results