Bradley EK - Search Results

1

An integrated suite of modeling tools that empower scientists in structure- and property-based drug design.

Feng JA, Aliagas I, Bergeron P, Blaney JM, Bradley EK, Koehler MF, Lee ML, Ortwine DF, Tsui V, Wu J, Gobbi A. Feng JA, et al. Among authors: bradley ek. J Comput Aided Mol Des. 2015 Jun;29(6):511-23. doi: 10.1007/s10822-015-9845-4. Epub 2015 Apr 29. J Comput Aided Mol Des. 2015. PMID: 25921252

2

Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.

Staben ST, Blaquiere N, Tsui V, Kolesnikov A, Do S, Bradley EK, Dotson J, Goldsmith R, Heffron TP, Lesnick J, Lewis C, Murray J, Nonomiya J, Olivero AG, Pang J, Rouge L, Salphati L, Wei B, Wiesmann C, Wu P. Staben ST, et al. Among authors: bradley ek. Bioorg Med Chem Lett. 2013 Feb 1;23(3):897-901. doi: 10.1016/j.bmcl.2012.10.121. Epub 2012 Nov 5. Bioorg Med Chem Lett. 2013. PMID: 23265894

3

NMR structural characterization of oligo-N-substituted glycine lead compounds from a combinatorial library.

Bradley EK, Kerr JM, Richter LS, Figliozzi GM, Goff DA, Zuckermann RN, Spellmeyer DC, Blaney JM. Bradley EK, et al. Mol Divers. 1997;3(1):1-15. doi: 10.1023/a:1009698309407. Mol Divers. 1997. PMID: 9527473

4

Coupling structure-based design with combinatorial chemistry: application of active site derived pharmacophores with informative library design.

Eksterowicz JE, Evensen E, Lemmen C, Brady GP, Lanctot JK, Bradley EK, Saiah E, Robinson LA, Grootenhuis PD, Blaney JM. Eksterowicz JE, et al. Among authors: bradley ek. J Mol Graph Model. 2002 Jun;20(6):469-77. doi: 10.1016/s1093-3263(01)00148-6. J Mol Graph Model. 2002. PMID: 12071281

5

Comparing performance of computational tools for combinatorial library design.

Evensen E, Eksterowicz JE, Stanton RV, Oshiro C, Grootenhuis PD, Bradley EK. Evensen E, et al. Among authors: bradley ek. J Med Chem. 2003 Nov 20;46(24):5125-8. doi: 10.1021/jm025618t. J Med Chem. 2003. PMID: 14613315

6

Potent and highly selective benzimidazole inhibitors of PI3-kinase delta.

Murray JM, Sweeney ZK, Chan BK, Balazs M, Bradley E, Castanedo G, Chabot C, Chantry D, Flagella M, Goldstein DM, Kondru R, Lesnick J, Li J, Lucas MC, Nonomiya J, Pang J, Price S, Salphati L, Safina B, Savy PP, Seward EM, Ultsch M, Sutherlin DP. Murray JM, et al. J Med Chem. 2012 Sep 13;55(17):7686-95. doi: 10.1021/jm300717c. Epub 2012 Aug 21. J Med Chem. 2012. PMID: 22877085

7

Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.

Ndubaku CO, Heffron TP, Staben ST, Baumgardner M, Blaquiere N, Bradley E, Bull R, Do S, Dotson J, Dudley D, Edgar KA, Friedman LS, Goldsmith R, Heald RA, Kolesnikov A, Lee L, Lewis C, Nannini M, Nonomiya J, Pang J, Price S, Prior WW, Salphati L, Sideris S, Wallin JJ, Wang L, Wei B, Sampath D, Olivero AG. Ndubaku CO, et al. J Med Chem. 2013 Jun 13;56(11):4597-610. doi: 10.1021/jm4003632. Epub 2013 Jun 3. J Med Chem. 2013. PMID: 23662903

8

Evaluation of a novel shape-based computational filter for lead evolution: application to thrombin inhibitors.

Srinivasan J, Castellino A, Bradley EK, Eksterowicz JE, Grootenhuis PD, Putta S, Stanton RV. Srinivasan J, et al. Among authors: bradley ek. J Med Chem. 2002 Jun 6;45(12):2494-500. doi: 10.1021/jm010494q. J Med Chem. 2002. PMID: 12036357

9

Studies of synthetic helical peptides using circular dichroism and nuclear magnetic resonance.

Bradley EK, Thomason JF, Cohen FE, Kosen PA, Kuntz ID. Bradley EK, et al. J Mol Biol. 1990 Oct 20;215(4):607-22. doi: 10.1016/S0022-2836(05)80172-X. J Mol Biol. 1990. PMID: 2231722

10

Sequence-specific polypeptoids: a diverse family of heteropolymers with stable secondary structure.

Kirshenbaum K, Barron AE, Goldsmith RA, Armand P, Bradley EK, Truong KT, Dill KA, Cohen FE, Zuckermann RN. Kirshenbaum K, et al. Among authors: bradley ek. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4303-8. doi: 10.1073/pnas.95.8.4303. Proc Natl Acad Sci U S A. 1998. PMID: 9539732 Free PMC article.

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