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Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates.
Byrareddy SN, Sidell N, Arthos J, Cicala C, Zhao C, Little DM, Dunbar P, Yang GX, Pierzchalski K, Kane MA, Mayne AE, Song B, Soares MA, Villinger F, Fauci AS, Ansari AA. Byrareddy SN, et al. Among authors: fauci as. J Immunol. 2015 Jun 15;194(12):5968-79. doi: 10.4049/jimmunol.1402866. Epub 2015 May 6. J Immunol. 2015. PMID: 25948815 Free PMC article.
Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection.
Byrareddy SN, Kallam B, Arthos J, Cicala C, Nawaz F, Hiatt J, Kersh EN, McNicholl JM, Hanson D, Reimann KA, Brameier M, Walter L, Rogers K, Mayne AE, Dunbar P, Villinger T, Little D, Parslow TG, Santangelo PJ, Villinger F, Fauci AS, Ansari AA. Byrareddy SN, et al. Among authors: fauci as. Nat Med. 2014 Dec;20(12):1397-400. doi: 10.1038/nm.3715. Epub 2014 Nov 24. Nat Med. 2014. PMID: 25419708 Free PMC article.
MAdCAM costimulation through Integrin-α4β7 promotes HIV replication.
Nawaz F, Goes LR, Ray JC, Olowojesiku R, Sajani A, Ansari AA, Perrone I, Hiatt J, Van Ryk D, Wei D, Waliszewski M, Soares MA, Jelicic K, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J. Nawaz F, et al. Among authors: fauci as. Mucosal Immunol. 2018 Sep;11(5):1342-1351. doi: 10.1038/s41385-018-0044-1. Epub 2018 Jun 6. Mucosal Immunol. 2018. PMID: 29875402 Free PMC article.
Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection.
Santangelo PJ, Cicala C, Byrareddy SN, Ortiz KT, Little D, Lindsay KE, Gumber S, Hong JJ, Jelicic K, Rogers KA, Zurla C, Villinger F, Ansari AA, Fauci AS, Arthos J. Santangelo PJ, et al. Among authors: fauci as. Mucosal Immunol. 2018 May;11(3):932-946. doi: 10.1038/mi.2017.112. Epub 2017 Dec 20. Mucosal Immunol. 2018. PMID: 29346349 Free PMC article.
HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
Arthos J, Cicala C, Martinelli E, Macleod K, Van Ryk D, Wei D, Xiao Z, Veenstra TD, Conrad TP, Lempicki RA, McLaughlin S, Pascuccio M, Gopaul R, McNally J, Cruz CC, Censoplano N, Chung E, Reitano KN, Kottilil S, Goode DJ, Fauci AS. Arthos J, et al. Among authors: fauci as. Nat Immunol. 2008 Mar;9(3):301-9. doi: 10.1038/ni1566. Epub 2008 Feb 10. Nat Immunol. 2008. PMID: 18264102
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.
Jelicic K, Cimbro R, Nawaz F, Huang da W, Zheng X, Yang J, Lempicki RA, Pascuccio M, Van Ryk D, Schwing C, Hiatt J, Okwara N, Wei D, Roby G, David A, Hwang IY, Kehrl JH, Arthos J, Cicala C, Fauci AS. Jelicic K, et al. Among authors: fauci as. Nat Immunol. 2013 Dec;14(12):1256-65. doi: 10.1038/ni.2746. Epub 2013 Oct 27. Nat Immunol. 2013. PMID: 24162774 Free PMC article.
Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy.
Byrareddy SN, Arthos J, Cicala C, Villinger F, Ortiz KT, Little D, Sidell N, Kane MA, Yu J, Jones JW, Santangelo PJ, Zurla C, McKinnon LR, Arnold KB, Woody CE, Walter L, Roos C, Noll A, Van Ryk D, Jelicic K, Cimbro R, Gumber S, Reid MD, Adsay V, Amancha PK, Mayne AE, Parslow TG, Fauci AS, Ansari AA. Byrareddy SN, et al. Among authors: fauci as. Science. 2016 Oct 14;354(6309):197-202. doi: 10.1126/science.aag1276. Science. 2016. PMID: 27738167 Free PMC article.
1,074 results