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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.
El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH. El-Naggar AM, et al. Among authors: negri gl. Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003. Cancer Cell. 2015. PMID: 25965573 Free article.
eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
Jan A, Jansonius B, Delaidelli A, Somasekharan SP, Bhanshali F, Vandal M, Negri GL, Moerman D, MacKenzie I, Calon F, Hayden MR, Taubert S, Sorensen PH. Jan A, et al. Among authors: negri gl. Acta Neuropathol. 2017 Jan;133(1):101-119. doi: 10.1007/s00401-016-1634-1. Epub 2016 Oct 17. Acta Neuropathol. 2017. PMID: 27752775
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity.
Jan A, Jansonius B, Delaidelli A, Bhanshali F, An YA, Ferreira N, Smits LM, Negri GL, Schwamborn JC, Jensen PH, Mackenzie IR, Taubert S, Sorensen PH. Jan A, et al. Among authors: negri gl. Acta Neuropathol Commun. 2018 Jul 2;6(1):54. doi: 10.1186/s40478-018-0554-9. Acta Neuropathol Commun. 2018. PMID: 29961428 Free PMC article.
HACE1 is a potential tumor suppressor in osteosarcoma.
El-Naggar AM, Clarkson PW, Negri GL, Turgu B, Zhang F, Anglesio MS, Sorensen PH. El-Naggar AM, et al. Among authors: negri gl. Cell Death Dis. 2019 Jan 8;10(1):21. doi: 10.1038/s41419-018-1276-4. Cell Death Dis. 2019. PMID: 30622235 Free PMC article.
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance.
Lim JKM, Delaidelli A, Minaker SW, Zhang HF, Colovic M, Yang H, Negri GL, von Karstedt S, Lockwood WW, Schaffer P, Leprivier G, Sorensen PH. Lim JKM, et al. Among authors: negri gl. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9433-9442. doi: 10.1073/pnas.1821323116. Epub 2019 Apr 18. Proc Natl Acad Sci U S A. 2019. PMID: 31000598 Free PMC article.
Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis.
El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB, Sorensen PH. El-Naggar AM, et al. Among authors: negri gl. EMBO Rep. 2019 Dec 5;20(12):e48375. doi: 10.15252/embr.201948375. Epub 2019 Oct 31. EMBO Rep. 2019. PMID: 31668005 Free PMC article.
66 results