Houghten RA - Search Results

1

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Eans SO, et al. Among authors: houghten ra. J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4. J Med Chem. 2015. PMID: 25996309

2

Opioid activity of 4-imidazolidinone positional analogues of Leu-Enkephalin.

Rinnová M, Nefzi A, Houghten RA. Rinnová M, et al. Among authors: houghten ra. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3175-8. doi: 10.1016/s0960-894x(02)00678-9. Bioorg Med Chem Lett. 2002. PMID: 12372527

3

De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library.

Houghten RA, Dooley CT, Appel JR. Houghten RA, et al. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1947-51. doi: 10.1016/j.bmcl.2004.01.090. Bioorg Med Chem Lett. 2004. PMID: 15050634

4

Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.

Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. Nefzi A, et al. Among authors: houghten ra. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4331-8. doi: 10.1016/j.bmcl.2006.05.053. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750366

5

Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.

Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K. Yongye AB, et al. Among authors: houghten ra. Bioorg Med Chem. 2009 Aug 1;17(15):5583-97. doi: 10.1016/j.bmc.2009.06.026. Epub 2009 Jun 21. Bioorg Med Chem. 2009. PMID: 19576786 Free PMC article.

6

Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.

Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Reilley KJ, et al. Among authors: houghten ra. AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27. AAPS J. 2010. PMID: 20422341 Free PMC article.

7

Discovery of novel antinociceptive α-conotoxin analogues from the direct in vivo screening of a synthetic mixture-based combinatorial library.

Armishaw CJ, Banerjee J, Ganno ML, Reilley KJ, Eans SO, Mizrachi E, Gyanda R, Hoot MR, Houghten RA, McLaughlin JP. Armishaw CJ, et al. Among authors: houghten ra. ACS Comb Sci. 2013 Mar 11;15(3):153-61. doi: 10.1021/co300152x. Epub 2013 Feb 27. ACS Comb Sci. 2013. PMID: 23414173

8

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.

Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, Yongye AB, Houghten RA, Yu Y. Hu M, et al. Among authors: houghten ra. Eur J Med Chem. 2015 Mar 6;92:270-81. doi: 10.1016/j.ejmech.2014.12.049. Epub 2014 Dec 29. Eur J Med Chem. 2015. PMID: 25559207

9

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.

10

Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[D-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation.

Li Y, Cazares M, Wu J, Houghten RA, Toll L, Dooley C. Li Y, et al. Among authors: houghten ra. J Med Chem. 2016 Feb 11;59(3):1239-45. doi: 10.1021/acs.jmedchem.5b01899. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26789491

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