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Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.
Miller BW, Morton JP, Pinese M, Saturno G, Jamieson NB, McGhee E, Timpson P, Leach J, McGarry L, Shanks E, Bailey P, Chang D, Oien K, Karim S, Au A, Steele C, Carter CR, McKay C, Anderson K, Evans TR, Marais R, Springer C, Biankin A, Erler JT, Sansom OJ. Miller BW, et al. Among authors: chang d. EMBO Mol Med. 2015 Aug;7(8):1063-76. doi: 10.15252/emmm.201404827. EMBO Mol Med. 2015. PMID: 26077591 Free PMC article.
Adjuvant chemotherapy in elderly patients with pancreatic cancer.
Nagrial AM, Chang DK, Nguyen NQ, Johns AL, Chantrill LA, Humphris JL, Chin VT, Samra JS, Gill AJ, Pajic M; Australian Pancreatic Cancer Genome Initiative; Pinese M, Colvin EK, Scarlett CJ, Chou A, Kench JG, Sutherland RL, Horvath LG, Biankin AV. Nagrial AM, et al. Among authors: chang dk. Br J Cancer. 2014 Jan 21;110(2):313-9. doi: 10.1038/bjc.2013.722. Epub 2013 Nov 21. Br J Cancer. 2014. PMID: 24263063 Free PMC article.
Pancreatic cancer genomics: where can the science take us?
Graham JS, Jamieson NB, Rulach R, Grimmond SM, Chang DK, Biankin AV. Graham JS, et al. Among authors: chang dk. Clin Genet. 2015 Sep;88(3):213-9. doi: 10.1111/cge.12536. Epub 2015 Jan 19. Clin Genet. 2015. PMID: 25388820 Review.
Investigating Various Thresholds as Immunohistochemistry Cutoffs for Observer Agreement.
Ali A, Bell S, Bilsland A, Slavin J, Lynch V, Elgoweini M, Derakhshan MH, Jamieson NB, Chang D, Brown V, Denley S, Orange C, McKay C, Carter R, Oien KA, Duthie FR. Ali A, et al. Among authors: chang d. Appl Immunohistochem Mol Morphol. 2017 Oct;25(9):599-608. doi: 10.1097/PAI.0000000000000357. Appl Immunohistochem Mol Morphol. 2017. PMID: 27093449 Free article.
PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance.
Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. Roy N, et al. Among authors: chang d. Genes Dev. 2016 Dec 15;30(24):2669-2683. doi: 10.1101/gad.291021.116. Genes Dev. 2016. PMID: 28087712 Free PMC article.
Defining the molecular pathology of pancreatic body and tail adenocarcinoma.
Dreyer SB, Jamieson NB, Upstill-Goddard R, Bailey PJ, McKay CJ; Australian Pancreatic Cancer Genome Initiative; Biankin AV, Chang DK. Dreyer SB, et al. Among authors: chang dk. Br J Surg. 2018 Jan;105(2):e183-e191. doi: 10.1002/bjs.10772. Br J Surg. 2018. PMID: 29341146 Free PMC article.
ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy.
Veenstra VL, Damhofer H, Waasdorp C, van Rijssen LB, van de Vijver MJ, Dijk F, Wilmink HW, Besselink MG, Busch OR, Chang DK, Bailey PJ, Biankin AV, Kocher HM, Medema JP, Li JS, Jiang R, Pierce DW, van Laarhoven HWM, Bijlsma MF. Veenstra VL, et al. Among authors: chang dk. Oncogenesis. 2018 Nov 16;7(11):87. doi: 10.1038/s41389-018-0096-9. Oncogenesis. 2018. PMID: 30442938 Free PMC article.
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.
Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA. Halbrook CJ, et al. Among authors: chang d. Cell Metab. 2019 Jun 4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28. Cell Metab. 2019. PMID: 30827862 Free PMC article.
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy.
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB, Chang D, Bailey P, Scarpa A, Lawlor R, Chelala C, Keyse SM, Biankin A, Morton JP, Evans TJ, Barry ST, Sansom OJ, Kocher HM, Marshall JF. Reader CS, et al. Among authors: chang d. J Pathol. 2019 Nov;249(3):332-342. doi: 10.1002/path.5320. Epub 2019 Jul 30. J Pathol. 2019. PMID: 31259422 Free PMC article.
5,925 results