Ohtsu Y - Search Results

1

Regulated bioanalysis of conformers - A case study with ASP2151 in dog plasma and urine.

Ohtsu Y, Otsuka S, Nakamura T, Noguchi K. Ohtsu Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 1;997:56-63. doi: 10.1016/j.jchromb.2015.05.028. Epub 2015 May 28. J Chromatogr B Analyt Technol Biomed Life Sci. 2015. PMID: 26093120

2

Determination of ASP3258, a novel phosphodiesterase type 4 inhibitor, in rat plasma by high-performance liquid chromatography with fluorescence detection and its application to pharmacokinetic study.

Ohtsu Y, Takanuki F, Fukunaga Y, Noguchi K. Ohtsu Y, et al. Biomed Chromatogr. 2015 Feb;29(2):161-3. doi: 10.1002/bmc.3262. Epub 2014 Jun 16. Biomed Chromatogr. 2015. PMID: 24931801

3

Absorption, distribution, metabolism and excretion of novel phosphodiesterase type 4 inhibitor ASP3258 in rats.

Ohtsu Y, Sonoda T, Susaki Y, Tohda T, Fukunaga Y, Iwatsubo T, Noguchi K. Ohtsu Y, et al. Biopharm Drug Dispos. 2015 Jan;36(1):34-48. doi: 10.1002/bdd.1921. Epub 2014 Nov 22. Biopharm Drug Dispos. 2015. PMID: 25277346

4

Absorption, Distribution, Metabolism, and Excretion of the Novel Helicase-Primase Inhibitor, Amenamevir (ASP2151), in Rodents.

Ohtsu Y, Susaki Y, Noguchi K. Ohtsu Y, et al. Eur J Drug Metab Pharmacokinet. 2018 Dec;43(6):693-706. doi: 10.1007/s13318-018-0481-y. Eur J Drug Metab Pharmacokinet. 2018. PMID: 29748821 Free PMC article.

5

Pharmacokinetics and pharmacodynamics of ASP2151, a helicase-primase inhibitor, in a murine model of herpes simplex virus infection.

Katsumata K, Chono K, Kato K, Ohtsu Y, Takakura S, Kontani T, Suzuki H. Katsumata K, et al. Among authors: ohtsu y. Antimicrob Agents Chemother. 2013 Mar;57(3):1339-46. doi: 10.1128/AAC.01803-12. Epub 2012 Dec 28. Antimicrob Agents Chemother. 2013. PMID: 23274658 Free PMC article.

6

An Open-Label, Single-Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults.

Kato K, den Adel M, Groenendaal-van de Meent D, Ohtsu Y, Takada A, Katashima M. Kato K, et al. Among authors: ohtsu y. Clin Pharmacol Drug Dev. 2019 Jul;8(5):595-602. doi: 10.1002/cpdd.630. Epub 2018 Nov 9. Clin Pharmacol Drug Dev. 2019. PMID: 30412362 Free PMC article. Clinical Trial.

7

Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs.

Ohtsu Y, Gibbons JA, Suzuki K, Fitzsimmons ME, Nozawa K, Arai H. Ohtsu Y, et al. Eur J Drug Metab Pharmacokinet. 2017 Aug;42(4):611-626. doi: 10.1007/s13318-016-0374-x. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27590197

8

Pharmacokinetics and Safety of Amenamevir in Healthy Subjects: Analysis of Four Randomized Phase 1 Studies.

Kusawake T, Keirns JJ, Kowalski D, den Adel M, Groenendaal-van de Meent D, Takada A, Ohtsu Y, Katashima M. Kusawake T, et al. Among authors: ohtsu y. Adv Ther. 2017 Dec;34(12):2625-2637. doi: 10.1007/s12325-017-0642-4. Epub 2017 Nov 13. Adv Ther. 2017. PMID: 29134426 Free PMC article. Clinical Trial.

9

Current situation on biomarker validation in Japan.

Saito Y, Katori N, Ohtsu Y. Saito Y, et al. Among authors: ohtsu y. Bioanalysis. 2018 Jun 1;10(12):901-903. doi: 10.4155/bio-2017-0244. Epub 2018 Jun 20. Bioanalysis. 2018. PMID: 29923737 No abstract available.

10

Pharmacokinetic Evaluation of the Interactions of Amenamevir (ASP2151) with Ketoconazole, Rifampicin, Midazolam, and Warfarin in Healthy Adults.

Kusawake T, den Adel M, Groenendaal-van de Meent D, Garcia-Hernandez A, Takada A, Kato K, Ohtsu Y, Katashima M. Kusawake T, et al. Among authors: ohtsu y. Adv Ther. 2017 Nov;34(11):2466-2480. doi: 10.1007/s12325-017-0634-4. Epub 2017 Oct 26. Adv Ther. 2017. PMID: 29076107 Free PMC article.

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