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Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury.
Heery CR, Singh BH, Rauckhorst M, Marté JL, Donahue RN, Grenga I, Rodell TC, Dahut W, Arlen PM, Madan RA, Schlom J, Gulley JL. Heery CR, et al. Among authors: rodell tc. Cancer Immunol Res. 2015 Nov;3(11):1248-56. doi: 10.1158/2326-6066.CIR-15-0119. Epub 2015 Jun 30. Cancer Immunol Res. 2015. PMID: 26130065 Free PMC article. Clinical Trial.
Identification and characterization of a cytotoxic T-lymphocyte agonist epitope of brachyury, a transcription factor involved in epithelial to mesenchymal transition and metastasis.
Tucker JA, Jochems C, Boyerinas B, Fallon J, Greiner JW, Palena C, Rodell TC, Schlom J, Tsang KY. Tucker JA, et al. Among authors: rodell tc. Cancer Immunol Immunother. 2014 Dec;63(12):1307-17. doi: 10.1007/s00262-014-1603-2. Epub 2014 Sep 4. Cancer Immunol Immunother. 2014. PMID: 25186612 Free PMC article.
A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and Core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance.
King TH, Kemmler CB, Guo Z, Mann D, Lu Y, Coeshott C, Gehring AJ, Bertoletti A, Ho ZZ, Delaney W, Gaggar A, Subramanian GM, McHutchison JG, Shrivastava S, Lee YJ, Kottilil S, Bellgrau D, Rodell T, Apelian D. King TH, et al. PLoS One. 2014 Jul 22;9(7):e101904. doi: 10.1371/journal.pone.0101904. eCollection 2014. PLoS One. 2014. PMID: 25051027 Free PMC article.
Yeasts encoding tumour antigens in cancer immunotherapy.
Franzusoff A, Duke RC, King TH, Lu Y, Rodell TC. Franzusoff A, et al. Among authors: rodell tc. Expert Opin Biol Ther. 2005 Apr;5(4):565-75. doi: 10.1517/14712598.5.4.565. Expert Opin Biol Ther. 2005. PMID: 15934834 Review.
21 results