Reinhardt HC - Search Results

1

A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer.

Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozretić L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC. Dietlein F, et al. Among authors: reinhardt hc. Cell. 2015 Jul 2;162(1):146-59. doi: 10.1016/j.cell.2015.05.053. Cell. 2015. PMID: 26140595 Free article.

2

p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.

Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. Reinhardt HC, et al. Cancer Cell. 2007 Feb;11(2):175-89. doi: 10.1016/j.ccr.2006.11.024. Cancer Cell. 2007. PMID: 17292828 Free PMC article.

3

Cytokine-induced signaling networks prioritize dynamic range over signal strength.

Janes KA, Reinhardt HC, Yaffe MB. Janes KA, et al. Among authors: reinhardt hc. Cell. 2008 Oct 17;135(2):343-54. doi: 10.1016/j.cell.2008.08.034. Cell. 2008. PMID: 18957207 Free PMC article.

4

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Reinhardt HC, Yaffe MB. Reinhardt HC, et al. Curr Opin Cell Biol. 2009 Apr;21(2):245-55. doi: 10.1016/j.ceb.2009.01.018. Epub 2009 Feb 21. Curr Opin Cell Biol. 2009. PMID: 19230643 Free PMC article. Review.

5

The combined status of ATM and p53 link tumor development with therapeutic response.

Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT. Jiang H, et al. Among authors: reinhardt hc. Genes Dev. 2009 Aug 15;23(16):1895-909. doi: 10.1101/gad.1815309. Epub 2009 Jul 16. Genes Dev. 2009. PMID: 19608766 Free PMC article.

6

Exploiting synthetic lethal interactions for targeted cancer therapy.

Reinhardt HC, Jiang H, Hemann MT, Yaffe MB. Reinhardt HC, et al. Cell Cycle. 2009 Oct 1;8(19):3112-9. doi: 10.4161/cc.8.19.9626. Cell Cycle. 2009. PMID: 19755856 Free PMC article. Review.

7

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization.

Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB. Reinhardt HC, et al. Mol Cell. 2010 Oct 8;40(1):34-49. doi: 10.1016/j.molcel.2010.09.018. Mol Cell. 2010. PMID: 20932473 Free PMC article.

8

Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?

Reinhardt HC, Cannell IG, Morandell S, Yaffe MB. Reinhardt HC, et al. Cell Cycle. 2011 Jan 1;10(1):23-7. doi: 10.4161/cc.10.1.14351. Epub 2011 Jan 1. Cell Cycle. 2011. PMID: 21173571 Free PMC article. Review.

9

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway.

Habbig S, Bartram MP, Müller RU, Schwarz R, Andriopoulos N, Chen S, Sägmüller JG, Hoehne M, Burst V, Liebau MC, Reinhardt HC, Benzing T, Schermer B. Habbig S, et al. Among authors: reinhardt hc. J Cell Biol. 2011 May 16;193(4):633-42. doi: 10.1083/jcb.201009069. Epub 2011 May 9. J Cell Biol. 2011. PMID: 21555462 Free PMC article.

10

AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis.

Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. Höpker K, et al. Among authors: reinhardt hc. EMBO J. 2012 Oct 17;31(20):3961-75. doi: 10.1038/emboj.2012.236. Epub 2012 Aug 21. EMBO J. 2012. PMID: 22909821 Free PMC article.

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