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H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. Sen P, et al. Among authors: he c. Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115. Genes Dev. 2015. PMID: 26159996 Free PMC article.
Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.
He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, Patel B, Faulkner AR, Shaposhnikov MV, Tian R, Tsuchiya M, Kaeberlein M, Moskalev AA, Kennedy BK, Polymenis M. He C, et al. PLoS Genet. 2014 Dec 18;10(12):e1004860. doi: 10.1371/journal.pgen.1004860. eCollection 2014 Dec. PLoS Genet. 2014. PMID: 25521617 Free PMC article.
The yeast replicative aging model.
He C, Zhou C, Kennedy BK. He C, et al. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2690-2696. doi: 10.1016/j.bbadis.2018.02.023. Epub 2018 Mar 8. Biochim Biophys Acta Mol Basis Dis. 2018. PMID: 29524633 Free article. Review.
Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.
Yao Y, Tsuchiyama S, Yang C, Bulteau AL, He C, Robison B, Tsuchiya M, Miller D, Briones V, Tar K, Potrero A, Friguet B, Kennedy BK, Schmidt M. Yao Y, et al. Among authors: he c. PLoS Genet. 2015 Jan 28;11(1):e1004968. doi: 10.1371/journal.pgen.1004968. eCollection 2015 Jan. PLoS Genet. 2015. PMID: 25629410 Free PMC article.
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