Ohana P - Search Results

1

Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients.

Golan T, Grenader T, Ohana P, Amitay Y, Shmeeda H, La-Beck NM, Tahover E, Berger R, Gabizon AA. Golan T, et al. Among authors: ohana p. Cancer Med. 2015 Oct;4(10):1472-83. doi: 10.1002/cam4.491. Epub 2015 Jul 14. Cancer Med. 2015. PMID: 26172205 Free PMC article. Clinical Trial.

2

Pharmacologic Studies of a Prodrug of Mitomycin C in Pegylated Liposomes (Promitil(®)): High Stability in Plasma and Rapid Thiolytic Prodrug Activation in Tissues.

Amitay Y, Shmeeda H, Patil Y, Gorin J, Tzemach D, Mak L, Ohana P, Gabizon A. Amitay Y, et al. Among authors: ohana p. Pharm Res. 2016 Mar;33(3):686-700. doi: 10.1007/s11095-015-1819-7. Epub 2015 Nov 16. Pharm Res. 2016. PMID: 26572644

3

Targeting of pegylated liposomal mitomycin-C prodrug to the folate receptor of cancer cells: Intracellular activation and enhanced cytotoxicity.

Patil Y, Amitay Y, Ohana P, Shmeeda H, Gabizon A. Patil Y, et al. Among authors: ohana p. J Control Release. 2016 Mar 10;225:87-95. doi: 10.1016/j.jconrel.2016.01.039. Epub 2016 Jan 22. J Control Release. 2016. PMID: 26809007

4

Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy.

Tian X, Warner SB, Wagner KT, Caster JM, Zhang T, Ohana P, Gabizon AA, Wang AZ. Tian X, et al. Among authors: ohana p. Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):547-55. doi: 10.1016/j.ijrobp.2016.06.2457. Epub 2016 Jul 1. Int J Radiat Oncol Biol Phys. 2016. PMID: 27681751

5

Characterization of Pegylated Liposomal Mitomycin C Lipid-Based Prodrug (Promitil) by High Sensitivity Differential Scanning Calorimetry and Cryogenic Transmission Electron Microscopy.

Wei X, Patil Y, Ohana P, Amitay Y, Shmeeda H, Gabizon A, Barenholz Y. Wei X, et al. Among authors: ohana p. Mol Pharm. 2017 Dec 4;14(12):4339-4345. doi: 10.1021/acs.molpharmaceut.6b00865. Epub 2017 Oct 30. Mol Pharm. 2017. PMID: 28045540

6

Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA).

Patil Y, Shmeeda H, Amitay Y, Ohana P, Kumar S, Gabizon A. Patil Y, et al. Among authors: ohana p. Nanomedicine. 2018 Jun;14(4):1407-1416. doi: 10.1016/j.nano.2018.04.011. Epub 2018 Apr 19. Nanomedicine. 2018. PMID: 29680672

7

Chemo-Radiotherapy of Oligometastases of Colorectal Cancer With Pegylated Liposomal Mitomycin-C Prodrug (Promitil): Mechanistic Basis and Preliminary Clinical Experience.

Tahover E, Bar-Shalom R, Sapir E, Pfeffer R, Nemirovsky I, Turner Y, Gips M, Ohana P, Corn BW, Wang AZ, Gabizon AA. Tahover E, et al. Among authors: ohana p. Front Oncol. 2018 Nov 26;8:544. doi: 10.3389/fonc.2018.00544. eCollection 2018. Front Oncol. 2018. PMID: 30534533 Free PMC article.

8

Pharmacokinetics of mitomycin-c lipidic prodrug entrapped in liposomes and clinical correlations in metastatic colorectal cancer patients.

Gabizon AA, Tahover E, Golan T, Geva R, Perets R, Amitay Y, Shmeeda H, Ohana P. Gabizon AA, et al. Among authors: ohana p. Invest New Drugs. 2020 Oct;38(5):1411-1420. doi: 10.1007/s10637-020-00897-3. Epub 2020 Jan 18. Invest New Drugs. 2020. PMID: 31955309 Clinical Trial.

9

Development of Promitil®, a lipidic prodrug of mitomycin c in PEGylated liposomes: From bench to bedside.

Gabizon A, Shmeeda H, Tahover E, Kornev G, Patil Y, Amitay Y, Ohana P, Sapir E, Zalipsky S. Gabizon A, et al. Among authors: ohana p. Adv Drug Deliv Rev. 2020;154-155:13-26. doi: 10.1016/j.addr.2020.07.027. Epub 2020 Aug 7. Adv Drug Deliv Rev. 2020. PMID: 32777239 Review.

10

Liposome co-encapsulation of anti-cancer agents for pharmacological optimization of nanomedicine-based combination chemotherapy.

Gabizon A, Ohana P, Amitay Y, Gorin J, Tzemach D, Mak L, Shmeeda H. Gabizon A, et al. Among authors: ohana p. Cancer Drug Resist. 2021 Jun 19;4(2):463-484. doi: 10.20517/cdr.2020.87. eCollection 2021. Cancer Drug Resist. 2021. PMID: 35582027 Free PMC article.

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