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Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Pawlikowski JS, Brock C, Chen SC, Al-Olabi L, Nixon C, McGregor F, Paine S, Chanudet E, Lambie W, Holmes WM, Mullin JM, Richmond A, Wu H, Blyth K, King A, Kinsler VA, Adams PD. Pawlikowski JS, et al. Among authors: wu h. J Invest Dermatol. 2015 Nov;135(11):2902. doi: 10.1038/jid.2015.230. Epub 2015 Jul 16. J Invest Dermatol. 2015. PMID: 26178707 Free article. No abstract available.
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Pawlikowski JS, Brock C, Chen SC, Al-Olabi L, Nixon C, McGregor F, Paine S, Chanudet E, Lambie W, Holmes WM, Mullin JM, Richmond A, Wu H, Blyth K, King A, Kinsler VA, Adams PD. Pawlikowski JS, et al. Among authors: wu h. J Invest Dermatol. 2015 Aug;135(8):2093-2101. doi: 10.1038/jid.2015.114. Epub 2015 Mar 27. J Invest Dermatol. 2015. PMID: 25815427 Free PMC article.
Wnt signaling potentiates nevogenesis.
Pawlikowski JS, McBryan T, van Tuyn J, Drotar ME, Hewitt RN, Maier AB, King A, Blyth K, Wu H, Adams PD. Pawlikowski JS, et al. Among authors: wu h. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16009-14. doi: 10.1073/pnas.1303491110. Epub 2013 Sep 16. Proc Natl Acad Sci U S A. 2013. PMID: 24043806 Free PMC article.
Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest.
Dikovskaya D, Cole JJ, Mason SM, Nixon C, Karim SA, McGarry L, Clark W, Hewitt RN, Sammons MA, Zhu J, Athineos D, Leach JD, Marchesi F, van Tuyn J, Tait SW, Brock C, Morton JP, Wu H, Berger SL, Blyth K, Adams PD. Dikovskaya D, et al. Among authors: wu h. Cell Rep. 2015 Sep 1;12(9):1483-96. doi: 10.1016/j.celrep.2015.07.055. Epub 2015 Aug 20. Cell Rep. 2015. PMID: 26299965 Free PMC article.
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability.
Nelson DM, Jaber-Hijazi F, Cole JJ, Robertson NA, Pawlikowski JS, Norris KT, Criscione SW, Pchelintsev NA, Piscitello D, Stong N, Rai TS, McBryan T, Otte GL, Nixon C, Clark W, Riethman H, Wu H, Schotta G, Garcia BA, Neretti N, Baird DM, Berger SL, Adams PD. Nelson DM, et al. Among authors: wu h. Genome Biol. 2016 Jul 25;17(1):158. doi: 10.1186/s13059-016-1017-x. Genome Biol. 2016. PMID: 27457071 Free PMC article.
Lysosome-mediated processing of chromatin in senescence.
Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD. Ivanov A, et al. Among authors: wu h. J Cell Biol. 2013 Jul 8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1. J Cell Biol. 2013. PMID: 23816621 Free PMC article.
mTOR is activated in the majority of malignant melanomas.
Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP. Karbowniczek M, et al. Among authors: wu h. J Invest Dermatol. 2008 Apr;128(4):980-7. doi: 10.1038/sj.jid.5701074. Epub 2007 Oct 4. J Invest Dermatol. 2008. PMID: 17914450 Free article.
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