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Page 1
Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations.
de Maat S, Björkqvist J, Suffritti C, Wiesenekker CP, Nagtegaal W, Koekman A, van Dooremalen S, Pasterkamp G, de Groot PG, Cicardi M, Renné T, Maas C. de Maat S, et al. Among authors: bjorkqvist j. J Allergy Clin Immunol. 2016 Nov;138(5):1414-1423.e9. doi: 10.1016/j.jaci.2016.02.021. Epub 2016 Apr 6. J Allergy Clin Immunol. 2016. PMID: 27130860
Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions.
Sala-Cunill A, Björkqvist J, Senter R, Guilarte M, Cardona V, Labrador M, Nickel KF, Butler L, Luengo O, Kumar P, Labberton L, Long A, Di Gennaro A, Kenne E, Jämsä A, Krieger T, Schlüter H, Fuchs T, Flohr S, Hassiepen U, Cumin F, McCrae K, Maas C, Stavrou E, Renné T. Sala-Cunill A, et al. Among authors: bjorkqvist j. J Allergy Clin Immunol. 2015 Apr;135(4):1031-1043.e6. doi: 10.1016/j.jaci.2014.07.057. Epub 2014 Sep 18. J Allergy Clin Immunol. 2015. PMID: 25240785
A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk.
Larsson M, Rayzman V, Nolte MW, Nickel KF, Björkqvist J, Jämsä A, Hardy MP, Fries M, Schmidbauer S, Hedenqvist P, Broomé M, Pragst I, Dickneite G, Wilson MJ, Nash AD, Panousis C, Renné T. Larsson M, et al. Among authors: bjorkqvist j. Sci Transl Med. 2014 Feb 5;6(222):222ra17. doi: 10.1126/scitranslmed.3006804. Sci Transl Med. 2014. PMID: 24500405
Plasma kallikrein: the bradykinin-producing enzyme.
Björkqvist J, Jämsä A, Renné T. Björkqvist J, et al. Thromb Haemost. 2013 Sep;110(3):399-407. doi: 10.1160/TH13-03-0258. Epub 2013 Jul 11. Thromb Haemost. 2013. PMID: 23846131 Review.
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