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Comparative kinetics of Escherichia coli- and Staphylococcus aureus-specific activation of key immune pathways in mammary epithelial cells demonstrates that S. aureus elicits a delayed response dominated by interleukin-6 (IL-6) but not by IL-1A or tumor necrosis factor alpha.
Günther J, Esch K, Poschadel N, Petzl W, Zerbe H, Mitterhuemer S, Blum H, Seyfert HM. Günther J, et al. Among authors: seyfert hm. Infect Immun. 2011 Feb;79(2):695-707. doi: 10.1128/IAI.01071-10. Epub 2010 Nov 29. Infect Immun. 2011. PMID: 21115717 Free PMC article.
Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder.
Yang W, Zerbe H, Petzl W, Brunner RM, Günther J, Draing C, von Aulock S, Schuberth HJ, Seyfert HM. Yang W, et al. Among authors: seyfert hm. Mol Immunol. 2008 Mar;45(5):1385-97. doi: 10.1016/j.molimm.2007.09.004. Epub 2007 Oct 22. Mol Immunol. 2008. PMID: 17936907
108 results