Spencer J - Search Results

1

Arginine-containing peptides as potent inhibitors of VIM-2 metallo-β-lactamase.

Rotondo CM, Marrone L, Goodfellow VJ, Ghavami A, Labbé G, Spencer J, Dmitrienko GI, Siemann S. Rotondo CM, et al. Among authors: spencer j. Biochim Biophys Acta. 2015 Nov;1850(11):2228-38. doi: 10.1016/j.bbagen.2015.07.012. Epub 2015 Aug 1. Biochim Biophys Acta. 2015. PMID: 26238337

2

Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography.

Spencer J, Read J, Sessions RB, Howell S, Blackburn GM, Gamblin SJ. Spencer J, et al. J Am Chem Soc. 2005 Oct 19;127(41):14439-44. doi: 10.1021/ja0536062. J Am Chem Soc. 2005. PMID: 16218639

3

Crystal structure of Pseudomonas aeruginosa SPM-1 provides insights into variable zinc affinity of metallo-beta-lactamases.

Murphy TA, Catto LE, Halford SE, Hadfield AT, Minor W, Walsh TR, Spencer J. Murphy TA, et al. Among authors: spencer j. J Mol Biol. 2006 Mar 31;357(3):890-903. doi: 10.1016/j.jmb.2006.01.003. Epub 2006 Jan 23. J Mol Biol. 2006. PMID: 16460758

4

Assay platform for clinically relevant metallo-β-lactamases.

van Berkel SS, Brem J, Rydzik AM, Salimraj R, Cain R, Verma A, Owens RJ, Fishwick CW, Spencer J, Schofield CJ. van Berkel SS, et al. Among authors: spencer j. J Med Chem. 2013 Sep 12;56(17):6945-53. doi: 10.1021/jm400769b. Epub 2013 Aug 16. J Med Chem. 2013. PMID: 23898798 Free PMC article.

5

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition.

Brem J, van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland KD, Kawamura A, Spencer J, Claridge TD, McDonough MA, Schofield CJ. Brem J, et al. Among authors: spencer j. Nat Chem. 2014 Dec;6(12):1084-90. doi: 10.1038/nchem.2110. Epub 2014 Nov 17. Nat Chem. 2014. PMID: 25411887

6

Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates.

Ghavami A, Labbé G, Brem J, Goodfellow VJ, Marrone L, Tanner CA, King DT, Lam M, Strynadka NC, Pillai DR, Siemann S, Spencer J, Schofield CJ, Dmitrienko GI. Ghavami A, et al. Among authors: spencer j. Anal Biochem. 2015 Oct 1;486:75-7. doi: 10.1016/j.ab.2015.06.032. Epub 2015 Jul 2. Anal Biochem. 2015. PMID: 26142222

7

Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri.

Booth MP, Kosmopoulou M, Poirel L, Nordmann P, Spencer J. Booth MP, et al. Among authors: spencer j. PLoS One. 2015 Oct 9;10(10):e0140059. doi: 10.1371/journal.pone.0140059. eCollection 2015. PLoS One. 2015. PMID: 26451836 Free PMC article.

8

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.

Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: spencer j. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303030 Free PMC article.

9

Structural and Biochemical Characterization of Rm3, a Subclass B3 Metallo-β-Lactamase Identified from a Functional Metagenomic Study.

Salimraj R, Zhang L, Hinchliffe P, Wellington EM, Brem J, Schofield CJ, Gaze WH, Spencer J. Salimraj R, et al. Among authors: spencer j. Antimicrob Agents Chemother. 2016 Sep 23;60(10):5828-40. doi: 10.1128/AAC.00750-16. Print 2016 Oct. Antimicrob Agents Chemother. 2016. PMID: 27431213 Free PMC article.

10

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates.

Brem J, Cain R, Cahill S, McDonough MA, Clifton IJ, Jiménez-Castellanos JC, Avison MB, Spencer J, Fishwick CW, Schofield CJ. Brem J, et al. Among authors: spencer j. Nat Commun. 2016 Aug 8;7:12406. doi: 10.1038/ncomms12406. Nat Commun. 2016. PMID: 27499424 Free PMC article.

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