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FTY720 and two novel butterfly derivatives exert a general anti-inflammatory potential by reducing immune cell adhesion to endothelial cells through activation of S1P(3) and phosphoinositide 3-kinase.
Imeri F, Blanchard O, Jenni A, Schwalm S, Wünsche C, Zivkovic A, Stark H, Pfeilschifter J, Huwiler A. Imeri F, et al. Among authors: pfeilschifter j. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1283-92. doi: 10.1007/s00210-015-1159-5. Epub 2015 Aug 13. Naunyn Schmiedebergs Arch Pharmacol. 2015. PMID: 26267293 Free article.
Lipids as targets for novel anti-inflammatory therapies.
Huwiler A, Pfeilschifter J. Huwiler A, et al. Among authors: pfeilschifter j. Pharmacol Ther. 2009 Oct;124(1):96-112. doi: 10.1016/j.pharmthera.2009.06.008. Epub 2009 Jun 30. Pharmacol Ther. 2009. PMID: 19576246 Review.
Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.
Imeri F, Fallegger D, Zivkovic A, Schwalm S, Enzmann G, Blankenbach K, Meyer zu Heringdorf D, Homann T, Kleuser B, Pfeilschifter J, Engelhardt B, Stark H, Huwiler A. Imeri F, et al. Among authors: pfeilschifter j. Neuropharmacology. 2014 Oct;85:314-27. doi: 10.1016/j.neuropharm.2014.05.012. Epub 2014 May 23. Neuropharmacology. 2014. PMID: 24863045
Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis.
Imeri F, Stepanovska Tanturovska B, Zivkovic A, Enzmann G, Schwalm S, Pfeilschifter J, Homann T, Kleuser B, Engelhardt B, Stark H, Huwiler A. Imeri F, et al. Among authors: pfeilschifter j. Neuropharmacology. 2021 Mar 15;186:108464. doi: 10.1016/j.neuropharm.2021.108464. Epub 2021 Jan 16. Neuropharmacology. 2021. PMID: 33460688
712 results