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Page 1
Fibrin activates GPVI in human and mouse platelets.
Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP. Alshehri OM, et al. Among authors: watson sk, watson sp. Blood. 2015 Sep 24;126(13):1601-8. doi: 10.1182/blood-2015-04-641654. Epub 2015 Aug 17. Blood. 2015. PMID: 26282541 Free PMC article.
Fibrin and D-dimer bind to monomeric GPVI.
Onselaer MB, Hardy AT, Wilson C, Sanchez X, Babar AK, Miller JLC, Watson CN, Watson SK, Bonna A, Philippou H, Herr AB, Mezzano D, Ariëns RAS, Watson SP. Onselaer MB, et al. Among authors: watson sk, watson cn, watson sp. Blood Adv. 2017 Aug 15;1(19):1495-1504. doi: 10.1182/bloodadvances.2017007732. eCollection 2017 Aug 22. Blood Adv. 2017. PMID: 29296791 Free PMC article.
Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Alshehri OM, Montague S, Watson S, Carter P, Sarker N, Manne BK, Miller JL, Herr AB, Pollitt AY, O'Callaghan CA, Kunapuli S, Arman M, Hughes CE, Watson SP. Alshehri OM, et al. Biochem J. 2015 Jun 15;468(3):459-73. doi: 10.1042/BJ20150192. Epub 2015 Apr 7. Biochem J. 2015. PMID: 25849538
Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation mediated by glycoprotein VI.
Nicolson PLR, Hughes CE, Watson S, Nock SH, Hardy AT, Watson CN, Montague SJ, Clifford H, Huissoon AP, Malcor JD, Thomas MR, Pollitt AY, Tomlinson MG, Pratt G, Watson SP. Nicolson PLR, et al. Haematologica. 2018 Dec;103(12):2097-2108. doi: 10.3324/haematol.2018.193391. Epub 2018 Jul 19. Haematologica. 2018. PMID: 30026342 Free PMC article.
Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.
Dütting S, Vögtle T, Morowski M, Schiessl S, Schäfer CM, Watson SK, Hughes CE, Ackermann JA, Radtke D, Hermanns HM, Watson SP, Nitschke L, Nieswandt B. Dütting S, et al. Among authors: watson sk, watson sp. Circ Res. 2014 Jan 31;114(3):444-453. doi: 10.1161/CIRCRESAHA.114.302670. Epub 2013 Nov 21. Circ Res. 2014. PMID: 24265393 Free PMC article.
Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia.
Hardy AT, Palma-Barqueros V, Watson SK, Malcor JD, Eble JA, Gardiner EE, Blanco JE, Guijarro-Campillo R, Delgado JL, Lozano ML, Teruel-Montoya R, Vicente V, Watson SP, Rivera J, Ferrer-Marín F. Hardy AT, et al. Among authors: watson sk, watson sp. Thromb Haemost. 2018 Jun;118(6):1009-1020. doi: 10.1055/s-0038-1646924. Epub 2018 Apr 25. Thromb Haemost. 2018. PMID: 29695020 Free PMC article.
69 results