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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.
Hurez V, Dao V, Liu A, Pandeswara S, Gelfond J, Sun L, Bergman M, Orihuela CJ, Galvan V, Padrón Á, Drerup J, Liu Y, Hasty P, Sharp ZD, Curiel TJ. Hurez V, et al. Among authors: orihuela cj. Aging Cell. 2015 Dec;14(6):945-56. doi: 10.1111/acel.12380. Epub 2015 Aug 28. Aging Cell. 2015. PMID: 26315673 Free PMC article.
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs.
Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S, White ES, Richardson A, Le Saux CJ. Calhoun C, et al. Among authors: orihuela cj. J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):153-60. doi: 10.1093/gerona/glu241. Epub 2015 Jan 7. J Gerontol A Biol Sci Med Sci. 2016. PMID: 25568097 Free PMC article.
Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.
González-Juarbe N, Bradley KM, Shenoy AT, Gilley RP, Reyes LF, Hinojosa CA, Restrepo MI, Dube PH, Bergman MA, Orihuela CJ. González-Juarbe N, et al. Among authors: orihuela cj. Cell Death Differ. 2017 May;24(5):917-928. doi: 10.1038/cdd.2017.49. Epub 2017 Apr 7. Cell Death Differ. 2017. PMID: 28387756 Free PMC article.
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Miller RA, et al. Among authors: orihuela cj. J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25. J Gerontol A Biol Sci Med Sci. 2011. PMID: 20974732 Free PMC article.
Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization.
Blanchette-Cain K, Hinojosa CA, Akula Suresh Babu R, Lizcano A, Gonzalez-Juarbe N, Munoz-Almagro C, Sanchez CJ, Bergman MA, Orihuela CJ. Blanchette-Cain K, et al. Among authors: orihuela cj. mBio. 2013 Oct 15;4(5):e00745-13. doi: 10.1128/mBio.00745-13. mBio. 2013. PMID: 24129258 Free PMC article.
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
González-Juarbe N, Gilley RP, Hinojosa CA, Bradley KM, Kamei A, Gao G, Dube PH, Bergman MA, Orihuela CJ. González-Juarbe N, et al. Among authors: orihuela cj. PLoS Pathog. 2015 Dec 11;11(12):e1005337. doi: 10.1371/journal.ppat.1005337. eCollection 2015 Dec. PLoS Pathog. 2015. PMID: 26659062 Free PMC article.
113 results