Cuny GD - Search Results

1

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.

Canning P, Ruan Q, Schwerd T, Hrdinka M, Maki JL, Saleh D, Suebsuwong C, Ray S, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Degterev A, Bullock AN. Canning P, et al. Among authors: cuny gd. Chem Biol. 2015 Sep 17;22(9):1174-84. doi: 10.1016/j.chembiol.2015.07.017. Epub 2015 Aug 27. Chem Biol. 2015. PMID: 26320862 Free PMC article.

2

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT Jr. Liu Y, et al. Among authors: cuny gd. Chem Biol. 2003 Sep;10(9):837-46. doi: 10.1016/j.chembiol.2003.08.010. Chem Biol. 2003. PMID: 14522054

3

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. Ahn JS, et al. Among authors: cuny gd. Chem Biol. 2005 Jul;12(7):811-23. doi: 10.1016/j.chembiol.2005.05.011. Chem Biol. 2005. PMID: 16039528

4

Structure-activity relationship study of novel necroptosis inhibitors.

Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Teng X, et al. Among authors: cuny gd. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44. doi: 10.1016/j.bmcl.2005.07.077. Bioorg Med Chem Lett. 2005. PMID: 16153840

5

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.

Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Degterev A, et al. Among authors: cuny gd. Nat Chem Biol. 2005 Jul;1(2):112-9. doi: 10.1038/nchembio711. Epub 2005 May 29. Nat Chem Biol. 2005. PMID: 16408008

6

Structure-activity relationship study of tricyclic necroptosis inhibitors.

Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Jagtap PG, et al. Among authors: cuny gd. J Med Chem. 2007 Apr 19;50(8):1886-95. doi: 10.1021/jm061016o. Epub 2007 Mar 16. J Med Chem. 2007. PMID: 17361994

7

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors.

Teng X, Keys H, Jeevanandam A, Porco JA Jr, Degterev A, Yuan J, Cuny GD. Teng X, et al. Among authors: cuny gd. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40. doi: 10.1016/j.bmcl.2007.10.024. Epub 2007 Oct 17. Bioorg Med Chem Lett. 2007. PMID: 17964153 Free PMC article.

8

Identification of RIP1 kinase as a specific cellular target of necrostatins.

Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Degterev A, et al. Among authors: cuny gd. Nat Chem Biol. 2008 May;4(5):313-21. doi: 10.1038/nchembio.83. Nat Chem Biol. 2008. PMID: 18408713 Free PMC article.

9

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors.

Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Teng X, et al. Among authors: cuny gd. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3219-23. doi: 10.1016/j.bmcl.2008.04.048. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18467094 Free PMC article.

10

Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice.

You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. You Z, et al. Among authors: cuny gd. J Cereb Blood Flow Metab. 2008 Sep;28(9):1564-73. doi: 10.1038/jcbfm.2008.44. Epub 2008 May 21. J Cereb Blood Flow Metab. 2008. PMID: 18493258 Free PMC article.

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