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Haploid genetic screens in human cells identify host factors used by pathogens.
Carette JE, Guimaraes CP, Varadarajan M, Park AS, Wuethrich I, Godarova A, Kotecki M, Cochran BH, Spooner E, Ploegh HL, Brummelkamp TR. Carette JE, et al. Among authors: varadarajan m. Science. 2009 Nov 27;326(5957):1231-5. doi: 10.1126/science.1178955. Science. 2009. PMID: 19965467
Generation of iPSCs from cultured human malignant cells.
Carette JE, Pruszak J, Varadarajan M, Blomen VA, Gokhale S, Camargo FD, Wernig M, Jaenisch R, Brummelkamp TR. Carette JE, et al. Among authors: varadarajan m. Blood. 2010 May 20;115(20):4039-42. doi: 10.1182/blood-2009-07-231845. Epub 2010 Mar 16. Blood. 2010. PMID: 20233975 Free PMC article.
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.
Surface LE, Burrow DT, Li J, Park J, Kumar S, Lyu C, Song N, Yu Z, Rajagopal A, Bae Y, Lee BH, Mumm S, Gu CC, Baker JC, Mohseni M, Sum M, Huskey M, Duan S, Bijanki VN, Civitelli R, Gardner MJ, McAndrew CM, Ricci WM, Gurnett CA, Diemer K, Wan F, Costantino CL, Shannon KM, Raje N, Dodson TB, Haber DA, Carette JE, Varadarajan M, Brummelkamp TR, Birsoy K, Sabatini DM, Haller G, Peterson TR. Surface LE, et al. Among authors: varadarajan m. Sci Transl Med. 2020 May 20;12(544):eaav9166. doi: 10.1126/scitranslmed.aav9166. Sci Transl Med. 2020. PMID: 32434850 Free PMC article.
Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells.
Estoppey D, Hewett JW, Guy CT, Harrington E, Thomas JR, Schirle M, Cuttat R, Waldt A, Gerrits B, Yang Z, Schuierer S, Pan X, Xie K, Carbone W, Knehr J, Lindeman A, Russ C, Frias E, Hoffman GR, Varadarajan M, Ramadan N, Reece-Hoyes JS, Wang Q, Chen X, McAllister G, Roma G, Bouwmeester T, Hoepfner D. Estoppey D, et al. Among authors: varadarajan m. Sci Rep. 2017 Feb 16;7:42728. doi: 10.1038/srep42728. Sci Rep. 2017. PMID: 28205648 Free PMC article.
Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons.
Sanchez CG, Acker CM, Gray A, Varadarajan M, Song C, Cochran NR, Paula S, Lindeman A, An S, McAllister G, Alford J, Reece-Hoyes J, Russ C, Craig L, Capre K, Doherty C, Hoffman GR, Luchansky SJ, Polydoro M, Dolmetsch R, Elwood F. Sanchez CG, et al. Among authors: varadarajan m. Commun Biol. 2021 Jun 14;4(1):736. doi: 10.1038/s42003-021-02272-1. Commun Biol. 2021. PMID: 34127790 Free PMC article.
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms.
Wang Y, Mohseni M, Grauel A, Diez JE, Guan W, Liang S, Choi JE, Pu M, Chen D, Laszewski T, Schwartz S, Gu J, Mansur L, Burks T, Brodeur L, Velazquez R, Kovats S, Pant B, Buruzula G, Deng E, Chen JT, Sari-Sarraf F, Dornelas C, Varadarajan M, Yu H, Liu C, Lim J, Hao HX, Jiang X, Malamas A, LaMarche MJ, Geyer FC, McLaughlin M, Costa C, Wagner J, Ruddy D, Jayaraman P, Kirkpatrick ND, Zhang P, Iartchouk O, Aardalen K, Cremasco V, Dranoff G, Engelman JA, Silver S, Wang H, Hastings WD, Goldoni S. Wang Y, et al. Among authors: varadarajan m. Sci Rep. 2021 Jan 14;11(1):1399. doi: 10.1038/s41598-021-80999-x. Sci Rep. 2021. PMID: 33446805 Free PMC article.
40 results