vanAalten DMF - Search Results

1

A mutant O-GlcNAcase as a probe to reveal global dynamics of protein O-GlcNAcylation during Drosophila embryonic development.

Mariappa D, Selvan N, Borodkin V, Alonso J, Ferenbach AT, Shepherd C, Navratilova IH, vanAalten DMF. Mariappa D, et al. Among authors: vanaalten dmf. Biochem J. 2015 Sep 1;470(2):255-262. doi: 10.1042/BJ20150610. Epub 2015 Jul 14. Biochem J. 2015. PMID: 26348912 Free PMC article.

2

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM. Thomas CC, et al. Biochem J. 2001 Sep 1;358(Pt 2):287-94. doi: 10.1042/0264-6021:3580287. Biochem J. 2001. PMID: 11513726 Free PMC article.

3

TAK1-binding protein 1 is a pseudophosphatase.

Conner SH, Kular G, Peggie M, Shepherd S, Schüttelkopf AW, Cohen P, Van Aalten DM. Conner SH, et al. Biochem J. 2006 Nov 1;399(3):427-34. doi: 10.1042/BJ20061077. Biochem J. 2006. PMID: 16879102 Free PMC article.

4

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.

Dorfmueller HC, Borodkin VS, Schimpl M, Shepherd SM, Shpiro NA, van Aalten DM. Dorfmueller HC, et al. J Am Chem Soc. 2006 Dec 27;128(51):16484-5. doi: 10.1021/ja066743n. J Am Chem Soc. 2006. PMID: 17177381 Free PMC article.

5

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.

Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM. Hurtado-Guerrero R, et al. Biochem J. 2008 Oct 15;415(2):217-23. doi: 10.1042/BJ20081000. Biochem J. 2008. PMID: 18601654

6

Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death.

Pathak S, Dorfmueller HC, Borodkin VS, van Aalten DM. Pathak S, et al. Chem Biol. 2008 Aug 25;15(8):799-807. doi: 10.1016/j.chembiol.2008.06.010. Chem Biol. 2008. PMID: 18721751 Free PMC article.

7

Structural insights into mechanism and specificity of O-GlcNAc transferase.

Clarke AJ, Hurtado-Guerrero R, Pathak S, Schüttelkopf AW, Borodkin V, Shepherd SM, Ibrahim AF, van Aalten DM. Clarke AJ, et al. EMBO J. 2008 Oct 22;27(20):2780-8. doi: 10.1038/emboj.2008.186. Epub 2008 Sep 25. EMBO J. 2008. PMID: 18818698 Free PMC article.

8

Molecular mechanisms of O-GlcNAcylation.

Hurtado-Guerrero R, Dorfmueller HC, van Aalten DM. Hurtado-Guerrero R, et al. Curr Opin Struct Biol. 2008 Oct;18(5):551-7. doi: 10.1016/j.sbi.2008.09.005. Epub 2008 Oct 6. Curr Opin Struct Biol. 2008. PMID: 18822376 Review.

9

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation.

Dorfmueller HC, Borodkin VS, Schimpl M, van Aalten DM. Dorfmueller HC, et al. Biochem J. 2009 May 13;420(2):221-7. doi: 10.1042/BJ20090110. Biochem J. 2009. PMID: 19275764 Free PMC article.

10

ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM. Zeqiraj E, et al. PLoS Biol. 2009 Jun 9;7(6):e1000126. doi: 10.1371/journal.pbio.1000126. Epub 2009 Jun 9. PLoS Biol. 2009. PMID: 19513107 Free PMC article.

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