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Structure of the toxic core of α-synuclein from invisible crystals.
Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. Rodriguez JA, et al. Among authors: guenther el. Nature. 2015 Sep 24;525(7570):486-90. doi: 10.1038/nature15368. Epub 2015 Sep 9. Nature. 2015. PMID: 26352473 Free PMC article.
Inhibition of synucleinopathic seeding by rationally designed inhibitors.
Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS. Sangwan S, et al. Among authors: guenther el. Elife. 2020 Jan 2;9:e46775. doi: 10.7554/eLife.46775. Elife. 2020. PMID: 31895037 Free PMC article.
Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS).
Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. Sangwan S, et al. Among authors: guenther el. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):8770-8775. doi: 10.1073/pnas.1705091114. Epub 2017 Jul 31. Proc Natl Acad Sci U S A. 2017. PMID: 28760994 Free PMC article.