Jahnke W - Search Results

1

Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding.

Marzinzik AL, Amstutz R, Bold G, Bourgier E, Cotesta S, Glickman JF, Götte M, Henry C, Lehmann S, Hartwieg JC, Ofner S, Pellé X, Roddy TP, Rondeau JM, Stauffer F, Stout SJ, Widmer A, Zimmermann J, Zoller T, Jahnke W. Marzinzik AL, et al. Among authors: jahnke w. ChemMedChem. 2015 Nov;10(11):1884-91. doi: 10.1002/cmdc.201500338. Epub 2015 Sep 18. ChemMedChem. 2015. PMID: 26381451

2

Strategies for the NMR-based identification and optimization of allosteric protein kinase inhibitors.

Jahnke W, Blommers MJ, Fernández C, Zwingelstein C, Amstutz R. Jahnke W, et al. Chembiochem. 2005 Sep;6(9):1607-10. doi: 10.1002/cbic.200500100. Chembiochem. 2005. PMID: 16028302 No abstract available.

3

Library design for fragment based screening.

Schuffenhauer A, Ruedisser S, Marzinzik AL, Jahnke W, Blommers M, Selzer P, Jacoby E. Schuffenhauer A, et al. Among authors: jahnke w. Curr Top Med Chem. 2005;5(8):751-62. doi: 10.2174/1568026054637700. Curr Top Med Chem. 2005. PMID: 16101415 Review.

4

Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.

Rondeau JM, Bitsch F, Bourgier E, Geiser M, Hemmig R, Kroemer M, Lehmann S, Ramage P, Rieffel S, Strauss A, Green JR, Jahnke W. Rondeau JM, et al. Among authors: jahnke w. ChemMedChem. 2006 Feb;1(2):267-73. doi: 10.1002/cmdc.200500059. ChemMedChem. 2006. PMID: 16892359

5

Time efficient detection of protein-ligand interactions with the polarization optimized PO-WaterLOGSY NMR experiment.

Gossert AD, Henry C, Blommers MJ, Jahnke W, Fernández C. Gossert AD, et al. Among authors: jahnke w. J Biomol NMR. 2009 Apr;43(4):211-7. doi: 10.1007/s10858-009-9303-5. Epub 2009 Feb 11. J Biomol NMR. 2009. PMID: 19205897

6

Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.

Fabbro D, Manley PW, Jahnke W, Liebetanz J, Szyttenholm A, Fendrich G, Strauss A, Zhang J, Gray NS, Adrian F, Warmuth M, Pelle X, Grotzfeld R, Berst F, Marzinzik A, Cowan-Jacob SW, Furet P, Mestan J. Fabbro D, et al. Among authors: jahnke w. Biochim Biophys Acta. 2010 Mar;1804(3):454-62. doi: 10.1016/j.bbapap.2009.12.009. Biochim Biophys Acta. 2010. PMID: 20152788

7

An in vitro assay to measure targeted drug delivery to bone mineral.

Jahnke W, Henry C. Jahnke W, et al. ChemMedChem. 2010 May 3;5(5):770-6. doi: 10.1002/cmdc.201000016. ChemMedChem. 2010. PMID: 20209564

8

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay.

Jahnke W, Grotzfeld RM, Pellé X, Strauss A, Fendrich G, Cowan-Jacob SW, Cotesta S, Fabbro D, Furet P, Mestan J, Marzinzik AL. Jahnke W, et al. J Am Chem Soc. 2010 May 26;132(20):7043-8. doi: 10.1021/ja101837n. J Am Chem Soc. 2010. PMID: 20450175

9

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.

Jahnke W, Rondeau JM, Cotesta S, Marzinzik A, Pellé X, Geiser M, Strauss A, Götte M, Bitsch F, Hemmig R, Henry C, Lehmann S, Glickman JF, Roddy TP, Stout SJ, Green JR. Jahnke W, et al. Nat Chem Biol. 2010 Sep;6(9):660-6. doi: 10.1038/nchembio.421. Epub 2010 Aug 15. Nat Chem Biol. 2010. PMID: 20711197

10

SEC-TID: A Label-Free Method for Small-Molecule Target Identification.

Salcius M, Bauer AJ, Hao Q, Li S, Tutter A, Raphael J, Jahnke W, Rondeau JM, Bourgier E, Tallarico J, Michaud GA. Salcius M, et al. Among authors: jahnke w. J Biomol Screen. 2014 Jul;19(6):917-27. doi: 10.1177/1087057114522691. Epub 2014 Feb 19. J Biomol Screen. 2014. PMID: 24554445

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